| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T69 |
292-603 |
Sentence |
denotes |
For these reasons Schauwvlieghe et al. [13] developed the modified AspICU criteria to help diagnose IAPA which (in the absence of histology) essentially relies on mycological evidence of Aspergillus spp. in the form of a positive bronchoalveolar lavage (BAL) culture or positive galactomannan (GM) in serum/BAL. |
| T70 |
604-796 |
Sentence |
denotes |
Applying these modified AspICU criteria, five cases of CAPA in table 1 were “proven”, 11 “putative” and 17 might be considered putative but with caveats which have been described in the table. |
| T71 |
797-976 |
Sentence |
denotes |
For example, in many cases a tracheal aspirate, rather than BAL, provided the only mycological evidence of invasive aspergillosis (in the absence of tracheobronchitis/cavitation). |
| T72 |
977-1162 |
Sentence |
denotes |
There should therefore be caution about over-estimating the incidence of CAPA from such case series, which may include some patients with aspergillus colonisation or contamination only. |
| T73 |
1163-1605 |
Sentence |
denotes |
In the study by Alanio et al. [9] which reported evidence of CAPA in nine (33%) out of 27 ventilated patients who underwent BAL/tracheal aspirate, one case was defined based on a BAL GM of 0.89 (below the usual cut-off of 1.0), two based on tracheal aspirate rather than BAL culture, one based on a serum GM of 0.51 (cut-off being 0.50) and in four cases BAL culture was positive but BAL GM negative, which suggests a lack of tissue invasion. |
| T74 |
1606-1687 |
Sentence |
denotes |
Indeed, out of seven cases that were not treated with antifungals, five survived. |
| T75 |
1688-1887 |
Sentence |
denotes |
Accordingly, larger, prospective, multi-site studies are needed to refine the AspICU criteria for patients with COVID-19, as well as to estimate incidence and the impact of CAPA on survival [25, 26]. |
