LitCovid-sentences  

PMC:7376974 / 70374-72752 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T442 0-68 Sentence denotes HNMs have been shown to be powerful allies against viral infections.
T443 69-190 Sentence denotes In particular, metal or metal oxide NMs, once internalized, can regulate the radical production into infected host cells.
T444 191-339 Sentence denotes In this scenario, the NMs can work following two different mechanisms: (1) enhancing radical activity or (2) quenching ROS inside cell compartments.
T445 340-491 Sentence denotes In the first case, metal oxide NPs are able to convert superoxide ions into more reactive hydroxyl radical species via Fenton or Fenton-like reactions.
T446 492-631 Sentence denotes The excess of superoxide ions is able to oxidize the viral proteins and the genetic material and therefore efficiently block the infection.
T447 632-810 Sentence denotes This approach has been reported using ZnO NPs.117,118 In these studies, ZnO NPs have been successfully applied for the treatment of H1N1 influenza virus and Herpes simplex virus.
T448 811-954 Sentence denotes The preliminary results showed that PEGylated ZnO particles were able to efficiently reduce the viral infection with IC50 similar to acyclovir.
T449 955-1146 Sentence denotes More importantly, toxicity of ZnO was modulated by functionalization with PEG, which allowed a higher colloidal stability and a more controlled release of Zn2+ ions to catalyze ROS formation.
T450 1147-1352 Sentence denotes Indeed, ROS (e.g., superoxide and hydroxyl radicals) produced by the NPs should be highly reactive and should not only damage the exogenous biological molecules but also attack different cell compartments.
T451 1353-1426 Sentence denotes Overproduction of ROS may reduce virus spread but also induce cell death.
T452 1427-1606 Sentence denotes Interestingly, this approach is applicable only at the early infection stage (after 1 h incubation of the host cells with a virus), but it loses its activity at later time points.
T453 1607-1999 Sentence denotes These experimental evidences suggest that materials capable of triggering the formation of ROS are essential in the first phase of the viral replication, most probably inducing the arrest of the viral DNA polymerases, which is active in the first 1–3 h of viral contamination.117,118 This specific mechanism of action restricts ZnO NPs to an application only at the early stage of infections.
T454 2000-2141 Sentence denotes However, the same approach with other metals able to induce Fenton or Fenton-like reactions (e.g., Fe, Cu, and Mn) has not been reported yet.
T455 2142-2271 Sentence denotes The choice of proper capping agents may allow to control the metal ion release and thus tune the ROS-mediated antiviral activity.
T456 2272-2378 Sentence denotes We would like to take an advantage here to suggest the growth of the antiviral research in this direction.