| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T253 |
0-92 |
Sentence |
denotes |
Based on these studies, another class of multivalent fullerene dendrimers was then designed. |
| T254 |
93-236 |
Sentence |
denotes |
A fast and controlled synthetic route was developed to achieve giant globular multivalent fullerenes, containing hundreds of functional groups. |
| T255 |
237-414 |
Sentence |
denotes |
The first study was performed with tridecafullerenes containing 120 mannoses.69 The molecular structure is composed of 12 hexakis C60 surrounding a C60 core (Figure 6, route B). |
| T256 |
415-719 |
Sentence |
denotes |
Compared to the previous study, an IC50 3 orders of magnitude lower was measured on the inhibition of Ebola virus (Table 3).66,68 In order to present more carbohydrates at the periphery of the dendrimer, a trialkynyl pentaerythritol derivative allowed to afford a tridecafullerene with 360 carbohydrates. |
| T257 |
720-1142 |
Sentence |
denotes |
In this case, the molecule was synthesized with a C60 tridecafullerene bearing α(1,2)mannobioside.70 The use of this disaccharide was already investigated, showing an increase of affinity with DC-sign receptors by a factor of 3–4.71 The synthetic strategy exploited also the use of strain-promoted copper-free cycloaddition of azides to alkynes (SPAAC) for the coupling of the core fullerene to the surrounding fullerenes. |
| T258 |
1143-1225 |
Sentence |
denotes |
SPAAC allows an easier purification avoiding the removal of cytotoxic copper ions. |
| T259 |
1226-1337 |
Sentence |
denotes |
The inhibition performance of this molecule was studied in vitro with viral pseudoparticles of Dengue and Zika. |
| T260 |
1338-1448 |
Sentence |
denotes |
The comparison was made between 360 and 120 disaccharides tridecafullerenes and 36 disaccharide monofullerene. |
| T261 |
1449-1582 |
Sentence |
denotes |
The results highlighted a picomolar IC50 inhibition on both Zika and Dengue models for the 360 disaccharide glycofullerene (Table 3). |
| T262 |
1583-1697 |
Sentence |
denotes |
The ability to inhibit other types of viruses allows the use of glycofullerenes as broad spectrum antiviral drugs. |
| T263 |
1698-1794 |
Sentence |
denotes |
Moreover, the negligible toxicity to other cells proved the biocompatibility of these molecules. |
