LitCovid-sentences  

PMC:7376974 / 30403-34126 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T192 0-48 Sentence denotes Nanoparticles Generating Reactive Oxygen Species
T193 49-239 Sentence denotes One of the main advantages of using NPs compared to oxidized metals relies on the slow release of ions and clusters from these particles, leading to an enhancement of the antiviral activity.
T194 240-474 Sentence denotes Additionally, the use of metal NPs containing Cu or Fe in ionic form catalyzes the generation of radicals via Fenton and Fenton-like reactions oxidizing the capsid proteins and consequently blocking the viral infection at early stage.
T195 475-1177 Sentence denotes For instance, copper ions (derived from sulfates or iodide salts) have been widely used as antiviral agents because of their activity on several kinds of enveloped and non-enveloped viruses including influenza virus,49−51 herpes simplex virus52−54 and hepatitis A virus.55 Their mechanism of action relies on the formation of Cu+ ions (from soluble salts or nanoparticles) that generate hydroxyl radicals.56 The use of metallic copper nanostructures in the form of particles or sheets has shown only a moderate efficiency due to the low concentration and low release of Cu+.56 For these reasons, Cu+ salts, where the copper ions are readily present in their active monocationic form, have been favored.
T196 1178-1704 Sentence denotes In particular, CuI nanoparticles (stable at room temperature) have been extensively studied for deactivation of feline calicivirus56 and H1N1 pandemic influenza virus.57 However, the use of copper salts at high concentrations can irreversibly alter reactive oxygen species (ROS) homeostasis of healthy cells, provoking a general toxicity for the organism, limiting their applications to disinfection.56 Nanostructured cuprous and cupric oxides have been also extensively employed as antiviral agents for in vitro applications.
T197 1705-1914 Sentence denotes For instance, cuprous oxide nanoparticles (CuONPs) were successfully employed against hepatitis C.58 In particular, it was found that these NPs exerted a favorable antiviral activity with no cytotoxic effects.
T198 1915-2003 Sentence denotes CuONPs target the binding and entry step of viral infection to hepatic cells (Figure 5).
T199 2004-2142 Sentence denotes Similar results were reported on the use of CuONPs against HSV-1, however without any profound investigation on the antiviral mechanism.59
T200 2143-2285 Sentence denotes Figure 5 Huh7.5.1 cells at 72 h post-infection were stained with HCV-positive serum from patients (green signal) and with DAPI (blue signal).
T201 2286-2357 Sentence denotes Cuprous oxide NPs (CuONPs) are able to reduce viral infection in vitro.
T202 2358-2399 Sentence denotes Reproduced with permission from ref (58).
T203 2400-2428 Sentence denotes Copyright 2015 Elsevier B.V.
T204 2429-2649 Sentence denotes Alternatively, zinc salts have been successfully used as antimicrobial agents from research up to clinical trials for viral warts.60,61 More recently, ZnO nanoparticles (ZnONPs) were developed for the treatment of HSV-2.
T205 2650-2805 Sentence denotes ZnONPs were prepared with a tetrapod morphology.62 The results showed that they can mimic cell surface interacting with the HS present on the viral capsid.
T206 2806-3059 Sentence denotes Additionally, these particles have been used for photocatalysis showing to efficiently destroy the viral proteins upon UV irradiation.62 Besides all these interesting examples, in vivo applications are still needed to validate this therapeutic modality.
T207 3060-3166 Sentence denotes Due to the generation of high levels of ROS, the toxicity of copper nanoparticles has been widely debated.
T208 3167-3414 Sentence denotes The antiviral activity of copper nanoparticles is generally associated with the release of Cu+ ions in solution, thus the leakage of cytotoxic cationic species can be modulated by surface functionalization before in vitro and in vivo applications.
T209 3415-3527 Sentence denotes On the other side, the use of nanomaterials generating ROS can find applications in textile and surface coating.
T210 3528-3723 Sentence denotes The general broad virucidal efficiency of copper oxide nanoparticles shown for H1N1 pandemic influenza57 should be tested on SARS-Cov-2 and might be used for improving mask protection efficiency.