| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T35 |
0-99 |
Sentence |
denotes |
In our previous work, we used five different fragments of SARS-CoV-1 S protein to immunise rabbits. |
| T36 |
100-253 |
Sentence |
denotes |
A fragment corresponding to residues 1029 to 1192 in the S2 subunit of SARS-CoV-1 was found to stimulate neutralising antibodies against SARS-CoV-1 [19]. |
| T37 |
254-410 |
Sentence |
denotes |
This fragment was subsequently used to generate a panel of murine mAbs with their respective binding domains characterised and described in Lip et al. [20]. |
| T38 |
411-702 |
Sentence |
denotes |
One of them, mAb 1A9, which binds to the S protein through a recently identified epitope within the S2 subunit at amino acids 1111–1130, has the ability to bind and cross-neutralise pseudotyped viruses expressing the S protein of human SARS-CoV-1, civet SARS-CoV and bat SL-CoV strains [21]. |
| T39 |
703-951 |
Sentence |
denotes |
In this study, we aim to verify if the sequence of the immunogen used to generate mAb 1A9, as well as three other mAbs, is conserved in different coronaviruses and if these mAbs bind to the S protein of SARS-CoV-2 expressed in mammalian cell lines. |
| T40 |
952-1177 |
Sentence |
denotes |
Importantly, mAb 1A9 is investigated for its ability to detect the S protein in SARS-CoV-2 infected cells and purified S protein in a sandwich ELISA format when paired with another mAb binding to the S1 subunit of SARS-CoV-2. |
