| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T150 |
0-42 |
Sentence |
denotes |
Fig. 6 Mechanisms of Sterile Organ Injury. |
| T151 |
43-242 |
Sentence |
denotes |
Toxic insults initiate both controlled and uncontrolled cell death in endothelial cells leading to apoptotic/necrotic tissue and release of intracellular cell components into the extracellular space. |
| T152 |
243-438 |
Sentence |
denotes |
These include immunogenic compounds such as RNA and DAMPs (HMGB1, ATP and Histone) which bind to and activate specific TLRs, driving the NFkB-mediated transcription of pro-inflammatory cytokines. |
| T153 |
439-500 |
Sentence |
denotes |
Platelets adhere to the endothelium via ICAM-1 and Kindlin-3. |
| T154 |
501-594 |
Sentence |
denotes |
Activated platelets release Poly P, which activates Factor XII, and subsequently, complement. |
| T155 |
595-700 |
Sentence |
denotes |
This results in activation of the coagulation pathways and further tissue injury, edema and inflammation. |
| T156 |
701-788 |
Sentence |
denotes |
Activated T cells release pro-inflammatory mediators and can cause direct cytotoxicity. |
| T157 |
789-980 |
Sentence |
denotes |
High mobility group box (HMGB)-1, damage associated molecular patterns (DAMPS), toll-like receptors (TLR), reactive oxygen species (ROS), polyphosphates (Poly-P), adenosine triphosphate (ATP) |
| T158 |
981-1000 |
Sentence |
denotes |
(From Silk E et al. |
| T159 |
1001-1035 |
Sentence |
denotes |
Cell Death Disease 2017; 8: e2812. |
| T160 |
1036-1052 |
Sentence |
denotes |
With permission) |
