LitCovid-sentences  

PMC:7373848 / 21073-22452 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T147 0-101 Sentence denotes Cytokine-induced endothelial cell injury occurs in a variety of conditions including acute infection.
T148 102-163 Sentence denotes Tumor necrosis factor (TNF)-α is particularly cytotoxic [48].
T149 164-326 Sentence denotes The mechanism(s) for injury include recruitment and binding of monocytes, up-regulation of caspase-1, IL-1β and expression of pyroptosis-related factors (Fig. 6).
T150 327-369 Sentence denotes Fig. 6 Mechanisms of Sterile Organ Injury.
T151 370-569 Sentence denotes Toxic insults initiate both controlled and uncontrolled cell death in endothelial cells leading to apoptotic/necrotic tissue and release of intracellular cell components into the extracellular space.
T152 570-765 Sentence denotes These include immunogenic compounds such as RNA and DAMPs (HMGB1, ATP and Histone) which bind to and activate specific TLRs, driving the NFkB-mediated transcription of pro-inflammatory cytokines.
T153 766-827 Sentence denotes Platelets adhere to the endothelium via ICAM-1 and Kindlin-3.
T154 828-921 Sentence denotes Activated platelets release Poly P, which activates Factor XII, and subsequently, complement.
T155 922-1027 Sentence denotes This results in activation of the coagulation pathways and further tissue injury, edema and inflammation.
T156 1028-1115 Sentence denotes Activated T cells release pro-inflammatory mediators and can cause direct cytotoxicity.
T157 1116-1307 Sentence denotes High mobility group box (HMGB)-1, damage associated molecular patterns (DAMPS), toll-like receptors (TLR), reactive oxygen species (ROS), polyphosphates (Poly-P), adenosine triphosphate (ATP)
T158 1308-1327 Sentence denotes (From Silk E et al.
T159 1328-1362 Sentence denotes Cell Death Disease 2017; 8: e2812.
T160 1363-1379 Sentence denotes With permission)