| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T132 |
0-57 |
Sentence |
denotes |
Endothelial cells are a target for inflammatory mediators |
| T133 |
58-183 |
Sentence |
denotes |
Metabolic abnormalities, oxidative stress, chemokines, cytokines and by products of DAMPs cause endothelial cell injury [40]. |
| T134 |
184-328 |
Sentence |
denotes |
While the toxic effect(s) can be direct, impaired epi-genetic regulation and activation of resident neutrophils and macrophages also contribute. |
| T135 |
329-489 |
Sentence |
denotes |
Products of vascular injury recruit neutrophils through several signaling pathways, including PI3K/AKt/eNOS/NF-Kβ and ERK1/2/P38 MAPK-activated protein kinases. |
| T136 |
490-621 |
Sentence |
denotes |
Recruited neutrophils subsets promote inflammation and further injury by releasing TNF-α, IL-1 and IL-8, and forming NETs [41, 42]. |
| T137 |
622-782 |
Sentence |
denotes |
Endothelial cells produce macrovesicles in response to inflammatory conditions and inflammatory mediators, including cytokines, thrombin and complement 5a [43]. |
| T138 |
783-899 |
Sentence |
denotes |
In turn, the endothelial cell macrovesicles impair adherans junctions, promote neutrophil binding and release NETs. |
| T139 |
900-1219 |
Sentence |
denotes |
Released during periods of cell death and immune activation, histone, nucleosomes and NETs induce cytotoxicity by altering cell membrane permeability to calcium ions, activating TLRs on innate immune cells, stimulating NLRP3 inflammasome and complement systems, resulting in a sterile pro-inflammatory environment [44]. |
