| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T295 |
0-288 |
Sentence |
denotes |
We further found that this transcriptional mirroring of coronavirus entry receptors was not unique to the small intestine, but was also strongly present among renal proximal tubule epithelial cells, where ACE2, DPP4, and ANPEP expression tends to be observed in the same cellular subsets. |
| T296 |
289-452 |
Sentence |
denotes |
These observations suggest the existence of a transcriptional network spanning tissues and cell types which may drive and regulate coronavirus receptor expression. |
| T297 |
453-734 |
Sentence |
denotes |
The question of whether coronaviruses have evolved to exploit such a network may be relevant to pursue, particularly given that downregulation of ACE2 by SARS-CoV has been reported previously and is associated with poor clinical outcomes (Glowacka et al., 2010; Kuba et al., 2010). |
| T298 |
735-898 |
Sentence |
denotes |
It is possible that SARS-CoV-2 is also able to induce cleavage of ACE2 as a means of viral entry and concomitant production of inflammatory cytokines (e.g. TNF-α). |
| T299 |
899-1088 |
Sentence |
denotes |
However, the moderate homology of spike proteins between SARS-CoV and SARS-CoV-2 requires additional experimentation to understand if such a mechanism operates in infection with SARS-CoV-2. |
