| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T287 |
0-163 |
Sentence |
denotes |
We identified tongue keratinocytes and olfactory epithelia as novel ACE2-expressing cell populations and thus as important potential sites of SARS-CoV-2 infection. |
| T288 |
164-453 |
Sentence |
denotes |
This molecular fingerprint is a striking correlate to established clinical reports of dysgeusia (Anosmia AAO-HNS, 2020) and anosmia (ENT UK, 2020) in COVID-19 patients, which strongly implicate the gustatory and olfactory systems in SARS-CoV-2 pathogenesis and human-to-human transmission. |
| T289 |
454-736 |
Sentence |
denotes |
Tongue epithelial cells have also previously been shown to uptake Epstein-Barr virus (Tugizov et al., 2003), and importantly a recent study found that ACE2 is appreciably expressed in the tongue based on a small number of non-tumor bulk RNA-seq samples from TCGA (Xu et al., 2020b). |
| T290 |
737-952 |
Sentence |
denotes |
This same study further showed by scRNAseq that ACE2 expression is observed in a subset of the human tongue (but not other oral mucosal) epithelial cells, albeit in only ~0.5% of the recovered epithelial population. |
| T291 |
953-1298 |
Sentence |
denotes |
This data has unfortunately not been released for public consumption but certainly does provide preliminary support for our finding, particularly as the listed set of cluster-defining genes for this population (SFN, KRT6A, KRT10) is consistent with the tongue keratinocyte identify from the Tabula Muris data set (Figure 2—figure supplement 20). |
| T292 |
1299-1507 |
Sentence |
denotes |
We thus emphasize the imminent need for further generation of multi-omic expression data from large numbers of healthy and diseased human tongue samples drawn from a cohort of wide demographic representation. |
