| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T198 |
0-302 |
Sentence |
denotes |
To determine whether this maturation-correlated expression pattern is unique to ACE2, we computed cosine similarities between the ACE2 gene expression vector (Counts Per 10,000 [CP10K] values in ~6000 small intestinal enterocytes) and that of the ~15,700 other genes detected in this study (Figure 5A). |
| T199 |
303-482 |
Sentence |
denotes |
For this analysis, the vector space is constituted of the individual cells as the dimensions using the gene expression values to construct the vectors (see Materials and methods). |
| T200 |
483-628 |
Sentence |
denotes |
Interestingly, we found that ANPEP, the established entry receptor for HCoV-229E, showed the third highest cosine similarity to ACE2 (Figure 5B). |
| T201 |
629-766 |
Sentence |
denotes |
Further, DPP4, the entry receptor for MERS coronavirus, is also among the top 1% of similarly expressed genes by this metric (Figure 5B). |
| T202 |
767-1082 |
Sentence |
denotes |
We confirmed that both of these genes do indeed show a maturation-correlated transcriptional pattern similar to that of ACE2 (Figure 5C–D), highlighting an unexpected shared pattern of transcriptional heterogeneity among known coronavirus receptors in a cell population which may be relevant for viral transmission. |
