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PMC:7361557 JSONTXT 15 Projects

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Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes The impact of type 2 diabetes and its management on the prognosis of patients with severe COVID‐19
T2 99-107 Sentence denotes Xu et al
T3 109-117 Sentence denotes Abstract
T4 118-126 Sentence denotes Abstract
T5 128-138 Sentence denotes Background
T6 139-280 Sentence denotes Although T2DM patients with COVID‐19 develop a more severe condition compared to those without diabetes, the mechanisms for this are unknown.
T7 281-376 Sentence denotes Moreover, the impact of treatment with anti‐hyperglycemic drugs and glucocorticoids is unclear.
T8 378-385 Sentence denotes Methods
T9 386-593 Sentence denotes From 1584 COVID‐19 patients, 364 severe/critical COVID‐19 patients with clinical outcome were enrolled for the final analysis and patients without pre‐existing T2DM but elevated glucose levels were excluded.
T10 594-741 Sentence denotes Epidemiological data were obtained and clinical‐status evaluation carried out to assess the impact of T2DM and its management on clinical outcomes.
T11 743-750 Sentence denotes Results
T12 751-835 Sentence denotes Of 364 enrolled severe COVID‐19 inpatients, 114 (31.3%) cases had a history of T2DM.
T13 836-1016 Sentence denotes 27(23.7%) cases died in T2DM patients, who had more severe inflammation, coagulation activation, myocardia injury, hepatic injury, and kidney injury, compared with non‐DM patients.
T14 1017-1284 Sentence denotes In severe COVID‐19 patients with T2DM, we demonstrate a higher risk of all‐cause fatality with glucocorticoid treatment (Adjusted HR, 3.61; 95%CI, 1.14‐11.46; P = 0.029), and severe hyperglycemia (FPG ≥11.1 mmol/L) (Adjusted HR, 11.86; 95%CI, 1.21‐116.44; P = 0.034).
T15 1286-1297 Sentence denotes Conclusions
T16 1298-1407 Sentence denotes T2DM status aggravated the clinical condition of COVID‐19 patients and increased their critical illness risk.
T17 1408-1554 Sentence denotes Poor fasting blood glucose (≥ 11.1 mmol/L) and glucocorticoid treatment are associated with poor prognosis for T2DM patients with severe COVID‐19.
T18 1555-1594 Sentence denotes This article is protected by copyright.
T19 1595-1615 Sentence denotes All rights reserved.