| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T32 |
129-255 |
Sentence |
denotes |
Doses between 1 and 10 µg were sufficient to remove between 23 and 93% of IgM anti‐MAG antibody from blood in the mouse model. |
| T33 |
256-405 |
Sentence |
denotes |
Reductions in antibody were sustained for as long as 96 hr, demonstrating the pharmacologic feasibility of this highly specific therapeutic approach. |
| T34 |
406-546 |
Sentence |
denotes |
In addition the investigators showed that after exposure to PPSGG, there was no activation of B cells, including human IgM anti‐MAG B cells. |
| T35 |
547-612 |
Sentence |
denotes |
In addition, no activation of CD11b dendritic cells was observed. |
| T36 |
613-731 |
Sentence |
denotes |
These experiments provide some assurance on the safety of this approach, if it is translated to human clinical trials. |
| T37 |
732-824 |
Sentence |
denotes |
Engaging IgM targeting MAG with PPSGG appeared safe and effective in the pre‐clinical study. |
