LitCovid-sentences  

PMC:7361216 / 346-2275 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T6 0-263 Sentence denotes In a rare neurologic disease known as IgM monoclonal gammopathy the immune system targets a sulfated trisaccharide known as the Human Natural Killer‐1 (HNK‐1) epitope that comprises a constituent of the myelin sheath known as MAG (myelin‐associated glycoprotein).
T7 264-715 Sentence denotes This Editorial highlights a study by Aliu and colleagues in the current issue of the Journal of Neurochemistry, in which the investigators constructed a biodegradable poly‐l‐lysine backbone with multiple copies of this sulfated HNK‐1 trisaccharide. This decoy, poly(phenyl disodium 3‐O‐sulfo‐β‐d‐glucopyranuronate)‐(1→3)‐β‐d‐galactopyranoside, known as PPSGG, removed anti‐MAG IgM autoantibodies from the blood, while not activating the immune system.
T8 716-860 Sentence denotes These findings provide a path for the selective removal of a pathogenic set of antibodies that target the myelin sheath resulting in neuropathy.
T9 861-1179 Sentence denotes These findings are applicable to a parallel strategy for the generation of polysaccharides similar to those present in the receptor‐binding domain of CoViD‐19, which might inhibit viral adhesion to its receptor, the angiotensin‐converting enzyme‐2 (ACE2) protein, thereby impairing cellular uptake of the virus itself.
T10 1180-1344 Sentence denotes The deployment of complex polysaccharides that mimic actual COVID19 polysaccharides on the spike protein may also provide a feasible structural basis for a vaccine.
T11 1345-1460 Sentence denotes Carbohydrate mimics, if conjugated to a carrier or backbone, might provoke an immune response to the spike protein.
T12 1461-1691 Sentence denotes A vaccine that targets critical carbohydrates on COVID19, and then neutralizes the virus would recapitulate a successful strategy employed in other microbial vaccines, like the pneumococcal vaccines and the meningococcal vaccines.
T13 1692-1808 Sentence denotes These vaccines direct an immune response to complex carbohydrates and successfully prevent life‐threatening disease.
T14 1809-1929 Sentence denotes This paper provides lessons from a rare neurologic disease that may teach us strategies applicable to a global pandemic.