PMC:7358770 / 30848-32511 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T191 0-239 Sentence denotes Although SARS-CoV vaccines can protect against lethal infection, the addition of delta inulin-based polysaccharide adjuvant on day 3 post-challenge can significantly increase serum neutralizing-antibody titers and reduce lung virus titers.
T192 240-400 Sentence denotes It also shows that immunity achieved with delta inulin adjuvants is long-lived, thereby overcoming the natural tendency for rapidly waning coronavirus immunity.
T193 401-529 Sentence denotes This suggests that delta inulin polysaccharide adjuvants have the potential to develop more effective coronavirus vaccines [20].
T194 530-653 Sentence denotes In addition, some Chinese herbal medicinal polysaccharides have been used as safe and effective adjuvants [77,107,112,113].
T195 654-800 Sentence denotes APS as an adjuvant combined with influenza vaccine can improve the immune response and systemic humoral response to H5N1 virus infection [46,114].
T196 801-974 Sentence denotes APS can potentially be used as an immunomodulator for a foot-and-mouth disease virus (FMDV), which is an RNA virus vaccine, and provide better protection against FMDV [115].
T197 975-1182 Sentence denotes APS is also a potent adjuvant for hepatitis B DNA vaccine, and can enhance the immune responses of HBV DNA vaccine via promoting dendritic cells maturation and inhibit the regulatory T cells frequency [116].
T198 1183-1341 Sentence denotes Polysaccharide extract from RI exerts potent anti-IAV activity against human seasonal influenza viruses (H1N1 and H3N2) and AIV (H6N2 and H9N2) in vitro [49].
T199 1342-1511 Sentence denotes The polysaccharides also significantly reduced the expression of pro-inflammatory cytokines (IL-6) and strongly inhibited the protein expression of TLR-3 induced by PR8.
T200 1512-1663 Sentence denotes The polysaccharide extract from RI, therefore, has the potential to be used as an adjunct to antiviral therapy for the treatment of IAV infection [49].