| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T172 |
0-164 |
Sentence |
denotes |
In addition, our team found that PGS, a sulfated derivative of alginate, can effectively inhibit the expression and secretion of HBsAg and HBeAg in HepG2.2.15cells. |
| T173 |
165-366 |
Sentence |
denotes |
The anti-HBV mechanism of PGS may be associated with appropriate activation of NF-κB and Raf/MEK/ERK signaling pathways to enhance the interferon system, and interfere with HBV transcription (Fig. 7 ). |
| T174 |
367-521 |
Sentence |
denotes |
This study suggested that PGS merits further investigation as a novel anti-HBV agent aimed at modulating the host innate immune system in the future [42]. |
| T175 |
522-611 |
Sentence |
denotes |
These studies bring new ideas to the development of current anti-novel coronavirus drugs. |
| T176 |
612-676 |
Sentence |
denotes |
Fig. 7 The molecular mechanisms of PGS inhibits HBV replication. |
| T177 |
677-812 |
Sentence |
denotes |
Cellular NF-κB and Raf/MEK/ERK signaling pathways are associated with the activation of innate immune system such as interferon system. |
| T178 |
813-986 |
Sentence |
denotes |
PGS can bind and enter into HepG2.2.15 cells to activate the NF-κB and Raf/MEK/ERK pathways to enhance the interferon system, and indirectly suppress HBV transcription [42]. |
