PMC:7358770 / 16116-17328 JSON TXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE

Id	Subject	Object	Predicate	Lexical cue
T99	0-131	Sentence	denotes	After the outbreak of SARS in 2003, many survivors developed residual pulmonary fibrosis with increased severity in older patients.
T100	132-296	Sentence	denotes	Pulmonary fibrosis is caused by a hyperactive host response to lung injury mediated by epidermal growth factor receptor (EGFR) signaling in animal models (Fig. 5 ).
T101	297-425	Sentence	denotes	Inhibition of EGFR signaling can prevent an excessive fibrotic response to SARS-CoV and other respiratory viral infections [72].
T102	426-619	Sentence	denotes	Moreover, sulfated polysaccharides such as fucoidan and sulfated rhamnan, can interfere or inhibit the expression and activation of EGFR pathway, which may help to suppress coronavirus [73,74].
T103	620-781	Sentence	denotes	The understanding of how polysaccharides play a role in EGFR and other pro-fibrotic pathways after viral infection will provide new ideas for COVID-19 treatment.
T104	782-852	Sentence	denotes	Fig. 5 The illustration about potential role of EGFR in lung fibrosis.
T105	853-1007	Sentence	denotes	Physical injury or a pathogen ① initiates the wound healing response by damaging healthy tissue, releasing EGFR ligands ② and activating the EGFR pathway.
T106	1008-1091	Sentence	denotes	This results in an exaggerated wound healing response leading to a fibrotic lung ③.
T107	1092-1212	Sentence	denotes	The early use of inhibitors like tyrosine kinase ④ could prevent the normal progress of wound healing and fibrosis [72].