| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T84 |
0-172 |
Sentence |
denotes |
Natural products of HS and the allied polysaccharide, heparin, are involved and prevent infection by a range of viruses including S-associated coronavirus strain HSR1 [66]. |
| T85 |
173-284 |
Sentence |
denotes |
HS is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells [54]. |
| T86 |
285-453 |
Sentence |
denotes |
Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the novel SARS-CoV-2 coronavirus outbreak. |
| T87 |
454-620 |
Sentence |
denotes |
The surface plasmon resonance and circular dichroism were used to measure the interaction between the SARS-CoV-2 Spike S1 protein RBD (SARS-CoV-2 S1 RBD) and heparin. |
| T88 |
621-715 |
Sentence |
denotes |
Additionally, basic amino acids are known to dictate the binding between proteins and heparin. |
| T89 |
716-984 |
Sentence |
denotes |
Primary sequence analysis of the expressed protein domain and analysis of the modeled SARS-CoV-2 S1 RBD structure show that there are several potential heparin binding sites, and more importantly, theses patches of basic amino acids are exposed on the protein surface. |
| T90 |
985-1154 |
Sentence |
denotes |
This study has implications for the rapid development of a first-line therapeutic by repurposing heparin and for next-generation, tailor-made, GAG-based antivirals [66]. |
