LitCovid-sentences  

PMC:7358770 / 10685-13295 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T68 0-162 Sentence denotes Cell surface GAGs serve as co-receptors by increasing the local concentration of pathogens, so that they can more efficiently interact with their entry receptors.
T69 163-301 Sentence denotes Most coronavirus receptors of carbohydrate are mainly negatively charged, such as sulfated GAGs or glycans containing sialic acid [54,55].
T70 302-486 Sentence denotes S protein concentrated outside the virus contains the receptor binding domains (RBDs) at the N-terminal, such as MHV-CoV N-RBD and SARS C-RBD with their receptor (Fig. 2B–D) [7,56,57].
T71 487-648 Sentence denotes The coronavirus NL63 (CoV-NL63), and SARS-CoV use angiotensin-converting enzyme 2 (ACE2) as a primary receptor for infection of target cells (Fig. 2) [56,58,59].
T72 649-820 Sentence denotes Phylogenetically, SARS-CoV-2 is almost identical to SARS-CoV, sharing 79.6% genomic sequence identity [60], and use the same cell entry receptor, ACE2, as SARS-CoV [8,60].
T73 821-1043 Sentence denotes During infection, CoV first binds host cell via interaction between its S1-RBD and the cell membrane receptor, triggering conformational changes in the S2 subunit that result in virus fusion and entry into the target cell.
T74 1044-1203 Sentence denotes Viral RNA gradually forms mature virions through replication, transcription, and synthesis, and then is released from host cell (Fig. 4 ) [8,[60], [61], [62]].
T75 1204-1367 Sentence denotes However, the expression of ACE2 is not sufficient for infection, and HSPGs play important roles in the entry of some pathogens such as SARS-CoV [[63], [64], [65]].
T76 1368-1469 Sentence denotes A soluble HS was used to assess whether the attachment of HCoV-NL63 was mediated by HS proteoglycans.
T77 1470-1709 Sentence denotes Flow cytometric analysis showed that the adhesion of virus to LLC-Mk2 cells was completely inhibited in the presence of soluble HS, indicating the role of this molecule in adhesion to susceptible cells and possible also in cell entry [54].
T78 1710-1896 Sentence denotes Both CoV-NL63 and SARS-CoV initially bind to the HS on the cell surface, and virus entry depends on the HS interaction, indicating that HS can inhibit virus attachment and entry [22,54].
T79 1897-1947 Sentence denotes Fig. 4 Life cycle of highly pathogenic human CoVs.
T80 1948-2058 Sentence denotes These CoVs enter host cells by first binding to their respective cellular receptors via the surface S protein.
T81 2059-2135 Sentence denotes Viral genomic RNA is released and translated into viral polymerase proteins.
T82 2136-2429 Sentence denotes Viral RNA and nucleocapsid (N) structural protein are replicated, transcribed, or synthesized in the cytoplasm, whereas other viral structural proteins, including S, membrane (M), and envelope (E), are transcribed then translated in the endoplasmic reticulum (ER) and transported to the Golgi.
T83 2430-2610 Sentence denotes The viral RNA–N complex and S, M, and E proteins are further assembled in the ER–Golgi intermediate compartment (ERGIC) to form a mature virion, then released from host cells [62].