LitCovid-sentences  

PMC:7354481 / 5845-9095 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T38 0-243 Sentence denotes MicroRNAs (miRs) are non-coding RNAs of length approximately 20–22 nucleotides; they post-transcriptionally regulate gene expression by binding to the 3′-untranslated regions of target mRNAs, leading to degradation or translational inhibition.
T39 244-548 Sentence denotes Each miR can target hundreds of mRNAs within a given cell type, and a single mRNA is often the target of multiple miRs, and thus over half of the human transcriptome is predicted to be under miR regulation, embedding this post-transcriptional control pathway within nearly every biological process [4,5].
T40 549-642 Sentence denotes Virally expressed miRs have recently been discovered, especially in viruses with DNA genomes.
T41 643-806 Sentence denotes The best-known viral miRs are found mostly in herpesvirus families, where they enhance bilateral crosstalk between viral pathogenesis and host response mechanisms.
T42 807-951 Sentence denotes Additionally, it has been shown that different virus families such as delta bovine leukaemia virus and foamy retroviruses could encode miRs [6].
T43 952-1088 Sentence denotes As previously shown, viral miRs are critical in the immune evasion mechanisms, affecting host immunity-related gene regulation networks.
T44 1089-1245 Sentence denotes This bilateral effect results in a rapid increase during the virus resistance against host defence mechanisms and leads to their survival in host cells [7].
T45 1246-1484 Sentence denotes The scope of miR generation from ssRNA viral genomes has been controversial, mainly due to the potentially deleterious effect of ssRNA viral genome cleavage into pre-/pri-miRs, making it unavailable for packaging into new virus particles.
T46 1485-1607 Sentence denotes However, predictive studies on RNA viral genomes reveal RNA structures, which are conceivable Drosha and Dicer substrates.
T47 1608-1794 Sentence denotes One of the well-described annotations was performed for HIV to define HIV-1 TAR RNA, a 59-nt long sequence that could generate a stem-loop structure similar to the pre-miR structure [8].
T48 1795-1871 Sentence denotes The identified numbers of viral miRs are not as many as for other organisms.
T49 1872-2043 Sentence denotes One of the reasons for this is that viral miRs, due to their cytoplasmic location in host cells, render interaction with nuclear miR biogenesis elements of the host cells.
T50 2044-2132 Sentence denotes Another hypothesis is that the cleavage of the viral RNA genome could generate miRs [9].
T51 2133-2318 Sentence denotes According to data obtained using in silico screening, there are fewer identified virus miRs compared with other species, and their functional roles in host cells are not well described.
T52 2319-2430 Sentence denotes Therefore, greater effort is required to identify novel virally encoded miRs and to predict their host targets.
T53 2431-2510 Sentence denotes Conversely, host cell miRs may alter the biological effect of the viruses [10].
T54 2511-2930 Sentence denotes Several interactions between viruses and the miRs in the host cells have been reported: the virus may either avoid being targeted by the cellular miRs [11]; block the cellular miRs to regulate key proteins in main signalling pathways [12,13]; synthesize their own viral miRs to create a more favourable cellular environment to survive in the host cells [14], or simply use the cellular miRs to their own advantage [15].
T55 2931-3038 Sentence denotes It should also be noted that host cell miR repertoires change dramatically in response to various diseases.
T56 3039-3250 Sentence denotes Several underlying cardiovascular and lung conditions may significantly alter host miR expression, which would affect virus-host lung cell interactions, and may significantly determine the course of the disease.