| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T275 |
0-216 |
Sentence |
denotes |
Sudden cardiac death is a major problem amongst the unexplained deaths in COVID-19, and it has been identified that many of those patients suffered from primary myocardial fibrosis (PMF), without any known aetiology. |
| T276 |
217-512 |
Sentence |
denotes |
Recently, higher expression of miR-1468-3p was identified as a disease-associated and age-dependent cardiac biomarker, as it promotes cardiac fibrosis and cell senescence, although no difference was noted in the mature form of miR-1468 between healthy and COVID-19-diseased cardiac tissue [101]. |
| T277 |
513-691 |
Sentence |
denotes |
TGF-β1 plays a key role in fibrosis-related pathologies including cardiac fibrosis, and, furthermore, miR-1468 activates non-canonical TGF-β1 and MAPKs signalling pathways [101]. |
| T278 |
692-1211 |
Sentence |
denotes |
Moreover, miR-1468-5p expression has been found to be upregulated in regulatory T cells, which have a significant role in autoimmune disorders, transplant rejection, allergic diseases, and asthma [102]. miR-1468-5p has previously been associated with glioma, where it inhibits growth and cell cycle progression by targeting ribonucleotide reductase large subunit M1 (RRM1), based on a study on patients from the Chinese Glioma Genome Atlas [103]. miR-1468-5 is also linked to progressing hepatocellular carcinoma [104]. |
| T279 |
1212-1345 |
Sentence |
denotes |
Interestingly, in Alzheimer’s disease, miR-1468-5p has been identified to be at lower abundance compared with healthy controls [105]. |
| T280 |
1346-1472 |
Sentence |
denotes |
It has furthermore been identified as a biomarker in late seizure in patients with spontaneous intracerebral haemorrhage [49]. |
| T281 |
1473-1581 |
Sentence |
denotes |
The link between miR-1468-5 in viral infection and other comorbidities will need to be further investigated. |
