| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T262 |
0-168 |
Sentence |
denotes |
miR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. |
| T263 |
169-346 |
Sentence |
denotes |
Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. |
| T264 |
347-597 |
Sentence |
denotes |
Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. |
| T265 |
598-715 |
Sentence |
denotes |
Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. |
| T266 |
716-1034 |
Sentence |
denotes |
Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. |
| T267 |
1035-1253 |
Sentence |
denotes |
The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. |
| T268 |
1254-1357 |
Sentence |
denotes |
TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]. |
