| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T245 |
0-89 |
Sentence |
denotes |
“Glycosaminoglycan biosynthesis—heparan sulfate/heparin” was here related to miRs 3934-3. |
| T246 |
90-240 |
Sentence |
denotes |
Heparan sulfate proteoglycans have previously been identified to provide the binding sites for SARS-CoV-2 invasion at the early attachment phase [76]. |
| T247 |
241-365 |
Sentence |
denotes |
Furthermore, human coronavirus NL63 has been shown to utilise heparan sulfate proteoglycans for target cell attachment [77]. |
| T248 |
366-522 |
Sentence |
denotes |
This KEGG pathway has been related to Ebola virus, where heparan sulfate has been identified as an important mediator in polarised epithelial cells [78,79]. |
| T249 |
523-789 |
Sentence |
denotes |
In hepatitis C viral infection, the virus hijacks this pathway via interaction with apolipoprotein E for cell entry [63], while heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection [70]. |
| T250 |
790-981 |
Sentence |
denotes |
Endogenous HERV-K furthermore binds to heparin for cell entry [80], and, while heparin has been found to further Zika virus infection, it acts as an antiviral against Dengue replication [81]. |
| T251 |
982-1287 |
Sentence |
denotes |
Heparin sulphate is identified as an inhibitory regulator of porcine epidemic diarrhoea virus infection [82] and acts as an attachment factor for rabies virus entry and infection [83], as well as an enhancer of Nipah and Hendra virus infections, which are highly pathogenic, zoonotic paramyxoviruses [84]. |
| T252 |
1288-1396 |
Sentence |
denotes |
This highlights the importance of this KEGG pathway both in human, zoonotic and veterinary viral infections. |
