| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T167 |
0-117 |
Sentence |
denotes |
Recently, the N nucleocapsid gene-related putative miR candidates were shown through in silico prediction tools [38]. |
| T168 |
118-266 |
Sentence |
denotes |
In a similar manner, we determined miR-8066, a mature sequence found on SARS-CoV-2 genomes, in SARS-CoV-2 genome alignment analysis with human miRs. |
| T169 |
267-430 |
Sentence |
denotes |
Additionally, miR-8067, which possesses a similar biological role to miR-8066, was identified as a stem loop region sequence in all SARS-CoV-2 genomes (Figure S1). |
| T170 |
431-552 |
Sentence |
denotes |
Previous reports showed that both miRs are found in plasma samples of sepsis patients with severe clinical outcomes [39]. |
| T171 |
553-691 |
Sentence |
denotes |
Similar miR family members such as miR-8054, miR-8057, miR-8061, and miR-8068, were also found in a non-survivor group of sepsis patients. |
| T172 |
692-824 |
Sentence |
denotes |
It has been shown by in silico analysis that certain miRNAs have the core motifs of AUUGUUG, and that miR-8066 is one of these [40]. |
| T173 |
825-1057 |
Sentence |
denotes |
When miRs have this motif, it increases their likelihood to bind and activate Nf κB-mediated TLR-8 expression and induce cytokine synthesis [40]. miR-8066 was identified at high levels in tissue biopsies as well as in exosomes [41]. |
| T174 |
1058-1247 |
Sentence |
denotes |
Therefore, SARS-CoV-2-mediated alterations of miRs may act as autocrine or paracrine agonists of host cells to trigger pro-inflammatory cytokines, due to their increased NfKB activity [42]. |
| T175 |
1248-1378 |
Sentence |
denotes |
Similar findings were also suggested for cancer cells, which showed miR alterations in association with inflammation markers [43]. |
