LitCovid-sentences  

PMC:7354481 / 20816-22570 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T140 0-4 Sentence denotes 3.2.
T141 5-105 Sentence denotes Analysis of Gene Alterations in NHEB Bronchial Epithelial and A549 Cells Due to SARS-CoV-2 Infection
T142 106-286 Sentence denotes In the final part of the study, we analyzed the gene expression alterations due to SARS-CoV-2-mediated infection in NHEB bronchial epithelial cells and A549 lung cancer cell lines.
T143 287-418 Sentence denotes For this purpose, we used the Bioproject PRJNA615032 publicly available data with the Rosalind bioinformatics data analysis server.
T144 419-532 Sentence denotes The meta-analysis results were evaluated for the differential gene expression at a 1.5 fold change cut-off level.
T145 533-733 Sentence denotes In total, 124 genes were selected according to a statistical p value threshold of <0.05, and analyzed for the related signaling axis to understand the disease pathophysiology, as shown in Figure 2A,B.
T146 734-825 Sentence denotes While 104 genes were upregulated in SARS-CoV-2-infected cells, 20 genes were downregulated.
T147 826-976 Sentence denotes All of these genes were also analysed using cluster analysis tools provided by the Rosalind bioinformatic data analysis server for different pathways.
T148 977-1152 Sentence denotes As shown in Table 4, the Wiki pathways, Bioplanet, KEGG, REACTOME, Panther, Pathway Interaction DB, and the number of virus-host response pathways, were significantly altered.
T149 1153-1282 Sentence denotes These significantly altered pathways showed correspondingly similar patterns with SARS-CoV-2-mediated known clinical pathologies.
T150 1283-1377 Sentence denotes These pathways were based on major differences of the target genes for inflammation responses.
T151 1378-1540 Sentence denotes The predicted pathways in cell lines showed similar significance with selected miRs that mainly target inflammation and virus pathogenesis (Figure 1 and Table 2).
T152 1541-1754 Sentence denotes Thus, we concluded that the selected miRs, that showed high similarity with human miRs, are also the critical targets, which project the major clinical pathophysiological conditions related to pathway alterations.