LitCovid-sentences  

PMC:7354481 / 197-2628 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T3 0-134 Sentence denotes Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a member of the betacoronavirus family, which causes COVID-19 disease.
T4 135-426 Sentence denotes SARS-CoV-2 pathogenicity in humans leads to increased mortality rates due to alterations of significant pathways, including some resulting in exacerbated inflammatory responses linked to the “cytokine storm” and extensive lung pathology, as well as being linked to a number of comorbidities.
T5 427-625 Sentence denotes Our current study compared five SARS-CoV-2 sequences from different geographical regions to those from SARS, MERS and two cold viruses, OC43 and 229E, to identify the presence of miR-like sequences.
T6 626-763 Sentence denotes We identified seven key miRs, which highlight considerable differences between the SARS-CoV-2 sequences, compared with the other viruses.
T7 764-939 Sentence denotes The level of conservation between the five SARS-CoV-2 sequences was identical but poor compared with the other sequences, with SARS showing the highest degree of conservation.
T8 940-1127 Sentence denotes This decrease in similarity could result in reduced levels of transcriptional control, as well as a change in the physiological effect of the virus and associated host-pathogen responses.
T9 1128-1226 Sentence denotes MERS and the milder symptom viruses showed greater differences and even significant sequence gaps.
T10 1227-1367 Sentence denotes This divergence away from the SARS-CoV-2 sequences broadly mirrors the phylogenetic relationships obtained from the whole-genome alignments.
T11 1368-1618 Sentence denotes Therefore, patterns of mutation, occurring during sequence divergence from the longer established human viruses to the more recent ones, may have led to the emergence of sequence motifs that can be related directly to the pathogenicity of SARS-CoV-2.
T12 1619-1811 Sentence denotes Importantly, we identified 7 key-microRNAs (miRs 8066, 5197, 3611, 3934-3p, 1307-3p, 3691-3p, 1468-5p) with significant links to KEGG pathways linked to viral pathogenicity and host responses.
T13 1812-1986 Sentence denotes According to Bioproject data (PRJNA615032), SARS-CoV-2 mediated transcriptomic alterations were similar to the target pathways of the selected 7 miRs identified in our study.
T14 1987-2105 Sentence denotes This mechanism could have considerable significance in determining the symptom spectrum of future potential pandemics.
T15 2106-2283 Sentence denotes KEGG pathway analysis revealed a number of critical pathways linked to the seven identified miRs that may provide insight into the interplay between the virus and comorbidities.
T16 2284-2431 Sentence denotes Based on our reported findings, miRNAs may constitute potential and effective therapeutic approaches in COVID-19 and its pathological consequences.