| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T730 |
0-44 |
Sentence |
denotes |
Lipid rafts are also viral attachment sites. |
| T731 |
45-363 |
Sentence |
denotes |
Viruses such as IBV, dengue virus, Ebola virus, hepatitis C virus, HIV, human herpes virus 6, measles virus, Newcastle disease virus, poliovirus, West Nile virus, foot-and-mouth disease virus, simian virus 40, rotavirus, influenza virus and Marburg virus also use lipid rafts for virus entry [151,152,153,154,155,156]. |
| T732 |
364-490 |
Sentence |
denotes |
In avian CoV IBV, structural proteins of the IBV virus are co-localized with PM lipid rafts embedded with the ganglioside GM1. |
| T733 |
491-623 |
Sentence |
denotes |
HCoV-229E entry is prevented by cholesterol depleted conditions because HCoV-229E clusters in caveolae-associated lipid rafts [157]. |
| T734 |
624-773 |
Sentence |
denotes |
Caveolae of caveolin-1, -2 and -3 are cross-linked [158] and control the molecular distribution between rafts and caveolae in a regulatory mechanism. |
| T735 |
774-843 |
Sentence |
denotes |
S protein-CD13 cross-linking occurs via CD13-caveolin-1 sequestering. |
| T736 |
844-919 |
Sentence |
denotes |
HCoV-229E particles similarly exhibit a longitudinal distribution property. |
| T737 |
920-996 |
Sentence |
denotes |
HCoV-229E-colocalized caveolin-1 undergoes the next step of virus infection. |
| T738 |
997-1117 |
Sentence |
denotes |
Caveolin-1 knockdown inhibited HCoV-229E endocytosis and entry and thus caveolin-1 is essential for HCoV-229E infection. |
| T739 |
1118-1193 |
Sentence |
denotes |
TGEV also endocytoses by a clathrin-mediated mechanism in MDCK cells [159]. |
| T740 |
1194-1298 |
Sentence |
denotes |
Other viruses including HCoV-OC43 also use an entry receptor sequestered to cross-linked caveolae [160]. |
| T741 |
1299-1408 |
Sentence |
denotes |
In SARS-CoV, the first entry step to host cells needs ACE2 in intact lipid rafts by the S glycoprotein [151]. |
| T742 |
1409-1525 |
Sentence |
denotes |
ACE2 is associated with caveolin-1 and GM1 in membrane rafts depending on its cell-type specific localization [161]. |
| T743 |
1526-1671 |
Sentence |
denotes |
Raft integrity with cholesterol and ACE2 is necessary for SARS-CoV pseudovirus entry into Vero E6 cells and for SARS-CoV-microdomain-based entry. |
| T744 |
1672-1769 |
Sentence |
denotes |
C-type lectin, CD209 L (L-SIGN), can also form lipid rafts and acts as a SARS-CoV receptor [162]. |
| T745 |
1770-1954 |
Sentence |
denotes |
Information of the CoV entry pathways is important for therapeutic designation of SARS-CoV-targeting drugs, for example, if agents disrupt lipid-raft localization of the ACE2 receptor. |
