PMC:7352545 / 64822-65745 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T625 0-6 Sentence denotes 6.3.9.
T626 7-103 Sentence denotes Tetraspanin CD9 is a Surface factor for MERS-CoV Entry Via Scaffold Cell Receptors and Proteases
T627 104-290 Sentence denotes Tetraspanin CD9, but not tetraspanin CD81, associates with DPP4 and the type II TM serine protease (TTSP) member TMPRSS2, a CoV-activating protease, to form a cell surface complex [131].
T628 291-379 Sentence denotes This CD9–DPP4–TMPRSS2 complex permits MERS-CoV pseudovirus entrance into the host cells.
T629 380-494 Sentence denotes The tetraspanins have four TM spanning regions linked by one large and one small loop in the extracellular region.
T630 495-561 Sentence denotes Tetraspanins form virus entry baselines and open CoV entry routes.
T631 562-652 Sentence denotes To help viral entry into host cells, MERS-CoV S interacts with DPP4 receptors via the RBD.
T632 653-747 Sentence denotes Receptor involvement causes cleavage using proteases such as the previously described TMPRSS2.
T633 748-837 Sentence denotes Association of tetraspanin CD9 with the DPP4–TMPRSS2 complex triggers the S glycoprotein.
T634 838-923 Sentence denotes MERS-CoVs enter the cells via endocytosis and cathepsins cleave the S proteins [132].