LitCovid-sentences  

PMC:7352545 / 60353-62117 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T581 0-129 Sentence denotes Among the six HCoVs, the α-CoV HCoV-229E S protein recognizes hAPN known as CD13 or membrane alanyl aminopeptidase (EC 3.4.11.2).
T582 130-262 Sentence denotes Porcine epidemic diarrhea coronavirus virus (PEDV) binds to protein receptor APN of human- and pig NeuAc species as its co-receptor.
T583 263-402 Sentence denotes Apart from hAPN, TGEV and PEDV bind to SA species [117], although SA recognition by TGEV is not essential in the first step of entry cycle.
T584 403-477 Sentence denotes HCoV-229E recognizes hAPN known as CD13 for its entry receptor. hAPN (PDB:
T585 478-586 Sentence denotes 4FYQ) or CD13 (EC 3.4.11.2), which is a Zn-dependent metalloprotease, has a MW 150 kDa with 967 amino acids.
T586 587-714 Sentence denotes CD13 is a type II TM protein with a short cytoplasmic domain in the N-terminal region and long extracellular region in the CTD.
T587 715-778 Sentence denotes The CTD has a pentapeptide sequence specific for the Zinc–MMPs.
T588 779-973 Sentence denotes The APN binding domain is located on the CTD of PEDV S1 (amino acid 477–629 residues), while the SA-binding domain is found in the N-terminal region of PEDV S1 (amino acid 1–320 residues) [118].
T589 974-1171 Sentence denotes CD13 is also a receptor for HCoV-229E, human cytomegalovirus, porcine CoV TGEV, feline infectious peritonitis virus (FIPV), feline enteric virus (FeCV) and canine-infectious CoVs [119,120,121,122].
T590 1172-1214 Sentence denotes Homodimeric CD13 digests luminal peptides.
T591 1215-1379 Sentence denotes The hAPN-encoding ANPEP gene is a dominant component in proximal tubular epithelial cells, small intestinal cells, macrophages, granulocytes and synaptic membranes.
T592 1380-1450 Sentence denotes If this gene is defective, leukemia or lymphoma are transformed [123].
T593 1451-1508 Sentence denotes Porcine and human APN exhibit about 80% protein identity.
T594 1509-1567 Sentence denotes FIPV and FeCV are in the same group as HCoV-229E and TGEV.
T595 1568-1661 Sentence denotes Thus, porcine APN is also an attachment site for pig TGEV with an additional second receptor.
T596 1662-1764 Sentence denotes HCoV-229E first binds to CD13 and consequently clusters CD13 in caveolae-associated lipid rafts [120].