LitCovid-sentences  

PMC:7352545 / 50204-52394 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T486 0-69 Sentence denotes TMPRSS2-cleaved ACE2 is involved in SARS-CoV and MERS-CoV infections.
T487 70-163 Sentence denotes SARS-CoV-2 uses ACE2 for cell entry through TMPRSS2 priming of the S glycoprotein (Figure 7).
T488 164-275 Sentence denotes Infection of the H7N9 influenza and H1N1 influenza A subtype viruses are also mediated by TMPRSS2-cleaved ACE2.
T489 276-356 Sentence denotes This implies that TMPRSS2 can be targeted as a strategic antiviral therapy [92].
T490 357-458 Sentence denotes Transmembrane protease serine 2, termed TMPRSS2, a type II TM Ser protease (TTSP), also cleaves ACE2.
T491 459-593 Sentence denotes The human TMPRSS2 gene, located on chromosome 21, comprises androgen receptor elements (AREs) in the upstream 5′-flanking region [93].
T492 594-658 Sentence denotes TMPRSS2 expression is regulated in an androgen-dependent manner.
T493 659-700 Sentence denotes The TMPRSS2 gene encodes 492 amino acids.
T494 701-786 Sentence denotes The original form is cleaved into the major membrane form and the minor soluble form.
T495 787-920 Sentence denotes TMPRSS2 activates protease activated receptor 2 (PAR-2) and activated PAR-2 upregulates matrix metalloproteinase-2 (MMP-2) and MMP-9.
T496 921-1003 Sentence denotes TMPRSS2-activated hepatocyte growth factor (HGF) induces c-Met receptor signaling.
T497 1004-1044 Sentence denotes TMPRSS2 activates SARS-CoV and MERS-CoV.
T498 1045-1256 Sentence denotes The SARS-CoV S glycoprotein is cleaved by host-borne TMPRSS2, human airway trypsin-like protease (HAT), TM protease, serine 13 (MSPL), serine protease DESC1 (DESC1), furin, factor Xa and endosomal cathepsin L/B.
T499 1257-1348 Sentence denotes SARS-CoV can enter cells upon cleavage by protease TMPRSS2 or endosomal cathepsin L/B [90].
T500 1349-1404 Sentence denotes Virus S protein precursor is cleaved by host proteases.
T501 1405-1541 Sentence denotes The spikes are cleaved by endosomal cathepsin and by Golgi or plasma membrane TMPRSS2 in the step of assembly or attachment and release.
T502 1542-1634 Sentence denotes The serine protease inhibitor camostat effectively blocks lethal SARS-CoV infection to mice.
T503 1635-1703 Sentence denotes However, serine protease and cathepsin inhibitors are not effective.
T504 1704-1813 Sentence denotes Thus, TMPRSS2 is suggested to be an acting protease for SARS-CoV entry into host cells, but not by cathepsin.
T505 1814-1906 Sentence denotes Cis-cleavage liberates SARS-CoV S glycoprotein fragments into the extracellular supernatant.
T506 1907-2048 Sentence denotes Trans-cleavage activates the SARS-CoV S glycoprotein on the target cells, potentiating efficient SARS-CoV S glycoprotein-driven viral fusion.
T507 2049-2121 Sentence denotes TMPRSS2-activated SARS-CoV facilitates enveloped virus entry into cells.
T508 2122-2190 Sentence denotes TMPRSS2 is important for SARS-CoV entry and infection [81,94,95,96].