| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T384 |
0-68 |
Sentence |
denotes |
The S glycoprotein SARS-CoV-2 initiates infection of the host cells. |
| T385 |
69-291 |
Sentence |
denotes |
The molecular basis of CoV attachment to sugar/glycan receptors is an important issue, as demonstrated by recent cryo-EM defining the structure of the CoV-OC43 S glycoprotein trimer complexed with a 9-O-acetylated SA [56]. |
| T386 |
292-514 |
Sentence |
denotes |
Cryo-EM structures of the trimeric ectodomain of S glycoprotein were observed using forms complexed with Neu5Ac, Neu5Gc, sialyl–LewisX (SLeX), α2,3-sialyl-N-acetyl-lactosamine (α2,3-SLacNAc) and α2,6-SLacNAc, respectively. |
| T387 |
515-768 |
Sentence |
denotes |
The receptor-binding site is commonly conserved in all CoV S glycoproteins, which attach to 9-O-Ac-SA species with similar ligand-binding pockets to the CoV HEs and influenza virus C/D HEF glycoproteins, indicating conserved recognizing structures [25]. |
| T388 |
769-910 |
Sentence |
denotes |
The S glycoprotein-9-O-acetyl-SA interaction resembles the ligand-binding pockets of CoV HEs and influenza virus C/D HE fusion glycoproteins. |
| T389 |
911-950 |
Sentence |
denotes |
HCoV-OC43 and BCoV recognize 9-O-Ac-SA. |
| T390 |
951-989 |
Sentence |
denotes |
S glycoproteins engage 9-O-acetyl-SAs. |
| T391 |
990-1231 |
Sentence |
denotes |
The 9-O-acetyl SAs are the binding site for HCoV-OC43 S glycoprotein and related β-1 CoV S glycoproteins, however SA-binding sites on the 9-O-acetyl sialyl receptors of MERS-CoV S glycoprotein and HCoV-OC43 S glycoprotein are different [71]. |
| T392 |
1232-1292 |
Sentence |
denotes |
Thus, CoVs use two different entry and attachment receptors. |
| T393 |
1293-1429 |
Sentence |
denotes |
Therefore, S glycoproteins of CoVs are distinct from influenza virus A HAs, which bind to the Neu5Ac species by conserved binding sites. |
| T394 |
1430-1683 |
Sentence |
denotes |
The ligand-binding sites of BCoV HE enzyme, influenza HEF enzyme and CoV S glycoprotein have evolved 9-O-Ac-SA binding through hydrogen bonding with the 9-O-acetyl carbonyl group and hydrophobic pocket formation with the 9-O-acetyl methyl group [71,72]. |
| T395 |
1684-1764 |
Sentence |
denotes |
However, influenza HA cannot bind to 9-O-acetyl-SAs but can bind to NeuGcs [73]. |
| T396 |
1765-2074 |
Sentence |
denotes |
The HCoV-OC43 S glycoprotein, HCoV-HKU1 S glycoprotein, BCoV S glycoprotein and PHEV S glycoprotein, therefore, share the ligand-binding specificity of influenza C/D HEF enzyme, although they are functionally more similar to influenza virus A/B HA, whereas CoV HE or influenza virus A/B NA have RDE activities |
