| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T373 |
0-140 |
Sentence |
denotes |
In torovirus, which belongs to the family Coronaviridae, the toroviruses are grouped into the Torovirinae subfamily and the Torovirus genus. |
| T374 |
141-256 |
Sentence |
denotes |
The known toroviruses can infect four species of hosts, constituting bovine, equine, porcine and human toroviruses. |
| T375 |
257-363 |
Sentence |
denotes |
They mildly infect swine and cattle through the HE protein, which is similar to the β-CoV HE protein [68]. |
| T376 |
364-457 |
Sentence |
denotes |
The HE protein is a class I membrane glycoprotein which forms homodimers with a MW of 65 kDa. |
| T377 |
458-533 |
Sentence |
denotes |
The RDE protein HE reversibly binds to glycans [15] through binding to SAs. |
| T378 |
534-583 |
Sentence |
denotes |
The acetyl-esterase activity disrupts SA binding. |
| T379 |
584-739 |
Sentence |
denotes |
HE hemagglutinates mouse erythrocytes and cleaves the acetyl-ester linkage of glycans and acetylated synthetic substrate p-nitrophenyl acetate (pNPA) [69]. |
| T380 |
740-903 |
Sentence |
denotes |
Similar to CoV, torovirus HE is an acetylesterase type, which cleaves the O-acetyl group from the SA C-9 position using Neu5,9Ac2 and N-acetyl-7(8),9-O-NeuAc [64]. |
| T381 |
904-1156 |
Sentence |
denotes |
However, torovirus HE exhibits a restricted specificity for the Neu5,9Ac2 substrate, but not for the Neu5,7(8),9Ac3 substrate, with a unique SA-binding site generated by a single amino acid difference in porcine Thr73 and bovine Ser64 for each HE [70]. |
