LitCovid-sentences  

PMC:7352545 / 34893-36719 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T342 0-111 Sentence denotes In β-CoV, HE mediates viral attachment to O-Ac-SAs and its function relies on the combined CBD and RDE domains.
T343 112-229 Sentence denotes Most β-CoVs target 9-O-Ac-SAs (type I), but certain strains switched to alternatively targeting 4-O-Ac-SAs (type II).
T344 230-379 Sentence denotes For example, the SA-acetylesterase enzyme in BCoVs and HCoV-OC43 is known to have hemagglutinizing activities as a type of SA-9-O-acetylesterase [8].
T345 380-441 Sentence denotes The SA-acetylesterase is the HE surface glycoprotein in BCoV.
T346 442-525 Sentence denotes The three-dimensional structure of BCoV HE is similar to other viral esterases [9].
T347 526-571 Sentence denotes The HE gene is found only in the β-CoV genus.
T348 572-743 Sentence denotes The acetylesterase of murine CoVs differs in its substrate binding specificity from that of BCoV and HCoV-OC43, which is specific for O-acetyl residue release from SA C-9.
T349 744-797 Sentence denotes Murine CoVs prefer to esterize 4-O-acetyl-NeuAc [64].
T350 798-907 Sentence denotes The β-CoV acetylesterase destroys the receptors and this specificity is similar to that of influenza viruses.
T351 908-1033 Sentence denotes Acetylesterase activity can be inhibited by diisopropyl fluorophosphate and this agent decreases viral infection levels [65].
T352 1034-1189 Sentence denotes As deduced from the SA acetylesterase of HCoV-OC43 [8], the 9-O-Ac-SA species is a receptor binding determinant for erythrocytes and entry into cells [59].
T353 1190-1257 Sentence denotes The BCoV HE protein has dual activity of acetylesterase and HA [9].
T354 1258-1379 Sentence denotes BCoV widely agglutinates erythrocytes and purified HE only agglutinates Neu5,9Ac2-enriched erythrocytes of rats and mice.
T355 1380-1462 Sentence denotes BCoV and HCoV-OC43 can agglutinate chicken erythrocytes, while purified HE cannot.
T356 1463-1650 Sentence denotes In contrast to the HE protein, purified S glycoprotein can agglutinate chicken erythrocytes [52], indicating that the major HA is the S protein which acts as the major SA-binding protein.
T357 1651-1826 Sentence denotes However, the role of O-Ac-SAs is not certain to be essential in receptors, and SA-binding activity may be essential only to the HE protein, but not to the S glycoprotein [54].