LitCovid-sentences  

PMC:7352545 / 33333-34870 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T328 0-103 Sentence denotes In α-CoVs such as TGEV, HA-activity is attributed to the SA-recognizing activity to α2,3-NeuGc [61,62].
T329 104-190 Sentence denotes The SA-binding site is present on the N-terminal region of the S-glycoprotein of TGEV.
T330 191-247 Sentence denotes TGEV has two types with enteric and respiratory tropism.
T331 248-346 Sentence denotes The respiratory TGEV has the porcine aminopeptidase N (pAPN)-binding domain and SA-binding domain.
T332 347-503 Sentence denotes Nucleotide 655 of the S gene is essential for enteric tropism and the S219A mutation of the S glycoprotein confers the enteric to respiratory tropism shift.
T333 504-672 Sentence denotes In addition, a 6-nucleotide insertional mutation at nucleotide 1124, which yields the Y374-T375insND shift of the S glycoprotein, causes enhanced enteric tract tropism.
T334 673-832 Sentence denotes TGEV interacts with SA species on mucin-like glycoprotein (MGP), a highly glycosylated protein, in an SA-dependent manner, on mucin-secreting goblet cells [6].
T335 833-917 Sentence denotes MGP SA-binding allows virus entry via the mucus layer to the intestinal enterocytes.
T336 918-1072 Sentence denotes Different from TGEV, the S glycoprotein of porcine CoV has no hemagglutination activity due to deletion of the SA-binding site of the S glycoprotein [61].
T337 1073-1150 Sentence denotes The loss of SA-binding activity is correlated to the non-enteropathogenicity.
T338 1151-1340 Sentence denotes SAs function as HA-mediated entry determinants for TGEV, causing the enteropathogenic outcome of the virus, and SA-recognition activity is also responsible for virus amplification in cells.
T339 1341-1450 Sentence denotes SA-binding activity-deficient TGEV can propagate in cells through pAPN, known as CD13, as a receptor [62,63].
T340 1451-1537 Sentence denotes The SA-binding activity potentiates infection and is crucial for intestinal infection.