LitCovid-sentences  

PMC:7352545 / 33312-34870 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T327 0-20 Sentence denotes 6.1.1. α-Coronavirus
T328 21-124 Sentence denotes In α-CoVs such as TGEV, HA-activity is attributed to the SA-recognizing activity to α2,3-NeuGc [61,62].
T329 125-211 Sentence denotes The SA-binding site is present on the N-terminal region of the S-glycoprotein of TGEV.
T330 212-268 Sentence denotes TGEV has two types with enteric and respiratory tropism.
T331 269-367 Sentence denotes The respiratory TGEV has the porcine aminopeptidase N (pAPN)-binding domain and SA-binding domain.
T332 368-524 Sentence denotes Nucleotide 655 of the S gene is essential for enteric tropism and the S219A mutation of the S glycoprotein confers the enteric to respiratory tropism shift.
T333 525-693 Sentence denotes In addition, a 6-nucleotide insertional mutation at nucleotide 1124, which yields the Y374-T375insND shift of the S glycoprotein, causes enhanced enteric tract tropism.
T334 694-853 Sentence denotes TGEV interacts with SA species on mucin-like glycoprotein (MGP), a highly glycosylated protein, in an SA-dependent manner, on mucin-secreting goblet cells [6].
T335 854-938 Sentence denotes MGP SA-binding allows virus entry via the mucus layer to the intestinal enterocytes.
T336 939-1093 Sentence denotes Different from TGEV, the S glycoprotein of porcine CoV has no hemagglutination activity due to deletion of the SA-binding site of the S glycoprotein [61].
T337 1094-1171 Sentence denotes The loss of SA-binding activity is correlated to the non-enteropathogenicity.
T338 1172-1361 Sentence denotes SAs function as HA-mediated entry determinants for TGEV, causing the enteropathogenic outcome of the virus, and SA-recognition activity is also responsible for virus amplification in cells.
T339 1362-1471 Sentence denotes SA-binding activity-deficient TGEV can propagate in cells through pAPN, known as CD13, as a receptor [62,63].
T340 1472-1558 Sentence denotes The SA-binding activity potentiates infection and is crucial for intestinal infection.