| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T298 |
0-62 |
Sentence |
denotes |
Type I HE is specific for the 9-O-acetylated SAs (9-O-Ac-SAs). |
| T299 |
63-101 |
Sentence |
denotes |
Type II HE is specific for 4-O-Ac-SAs. |
| T300 |
102-226 |
Sentence |
denotes |
The SA-binding shift indicates quasi-synchronous adaptations of the SA-recognition sites of the lectin and esterase domains. |
| T301 |
227-362 |
Sentence |
denotes |
Type I HE monomers of β-CoV lineage A have a bimodular enzyme–lectin domain similar to cellular glycan/carbohydrate-modifying proteins. |
| T302 |
363-567 |
Sentence |
denotes |
Originally, HE homologs are found in various viruses including toroviruses and orthomyxoviruses such as the influenza virus C/D and isavirus, as well as the exceptional case of β-CoV lineage A among CoVs. |
| T303 |
568-724 |
Sentence |
denotes |
The HE gene was transmitted to a β-CoV lineage A progenitor via horizontal gene transfer from a 9-O-Ac-Sia–recognizing HEF, as shown in influenza virus C/D. |
| T304 |
725-900 |
Sentence |
denotes |
HE acquisition and expansion occurred by cross-species transmission over HE evolution and this phenomenon reflects viral evolutionary adaptation to host SA-containing glycans. |
| T305 |
901-1013 |
Sentence |
denotes |
Therefore, CoV HE receptor switching precedes virus evolution driven by SA-containing glycan diversity of hosts. |
| T306 |
1014-1115 |
Sentence |
denotes |
For instance, the BcoV HE prefers 7,9-di-O-Ac-SAs, which is also a target of the bovine torovirus HE. |
| T307 |
1116-1259 |
Sentence |
denotes |
For a more outstanding case, such a switching event occurred in the murine CoVs for the β-CoV lineage A type switch toward O-Ac-SA recognition. |
| T308 |
1260-1504 |
Sentence |
denotes |
In the HE specificity of murine CoVs, two different murine CoV subtypes of virus group exist with one subtype possessing the typical 9-O-Ac-SA (type I) attachment factor and the other exclusively 4-O-Ac-SA (type II) attachment virus group [56]. |
