| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T285 |
0-77 |
Sentence |
denotes |
HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. |
| T286 |
78-141 |
Sentence |
denotes |
Coronaviral HEs are involved in virus attachment to SA species. |
| T287 |
142-250 |
Sentence |
denotes |
HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. |
| T288 |
251-364 |
Sentence |
denotes |
As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. |
| T289 |
365-433 |
Sentence |
denotes |
It contains a carbohydrate-recognizing domain (CRD) known in lectin. |
| T290 |
434-516 |
Sentence |
denotes |
The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. |
| T291 |
517-535 |
Sentence |
denotes |
HE is the only HA. |
| T292 |
536-669 |
Sentence |
denotes |
This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. |
| T293 |
670-892 |
Sentence |
denotes |
The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. |
| T294 |
893-970 |
Sentence |
denotes |
Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. |
| T295 |
971-1030 |
Sentence |
denotes |
However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. |
| T296 |
1031-1181 |
Sentence |
denotes |
The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. |
| T297 |
1182-1333 |
Sentence |
denotes |
In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]. |
