| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T259 |
0-6 |
Sentence |
denotes |
5.1.2. |
| T260 |
7-31 |
Sentence |
denotes |
Influenza C virus HA-HEF |
| T261 |
32-85 |
Sentence |
denotes |
HEF is indeed an ancient type of SA-O-acetylesterase. |
| T262 |
86-194 |
Sentence |
denotes |
In contrast to A/B, the influenza C virus bears one spike with triple functions of HEF as a homotrimer [46]. |
| T263 |
195-280 |
Sentence |
denotes |
Each HEF subunit bears two Neu5,9Ac2-binding sites and binds to the 9-O-acetyl group. |
| T264 |
281-341 |
Sentence |
denotes |
In parallel, another modification of O-acetylation is found. |
| T265 |
342-460 |
Sentence |
denotes |
Indeed, influenza C virus bears SA-O-acetylesterase [47], which converts 5-N-acetyl-9-O-NeuAc (Neu5,9Ac2) to 5-Neu5Ac. |
| T266 |
461-616 |
Sentence |
denotes |
The 9-O-acetyl SA is a unique determinant for the influenza C virus receptor and Neu5,9Ac2 is crucial for receptor activity, but not Neu5Gc or Neu5Ac [48]. |
| T267 |
617-709 |
Sentence |
denotes |
Neu5,9Ac2 is an essential determinant for influenza virus C type-specific host cell tropism. |
| T268 |
710-769 |
Sentence |
denotes |
NAs cleave the α-ketosidic linkages to the D-Gal or GalNAc. |
| T269 |
770-837 |
Sentence |
denotes |
SA-O-acetylesterases cleave different O-acetyl linkages (Figure 5). |
| T270 |
838-940 |
Sentence |
denotes |
The OH-group of Tyr224 and the guanidino group of Arg236 interact with the CH3CO-carbonyl oxygen [49]. |
| T271 |
941-1080 |
Sentence |
denotes |
HEF SA-O-acetylesterase is found in several enveloped (+) ssRNA viruses of influenza C virus and also in certain CoVs and toroviruses [47]. |
| T272 |
1081-1259 |
Sentence |
denotes |
The CoVs are different from the orthomyxoviruses, which hold a segmented (−) ssRNA genome and are instead evolutionary linked to the family Coronaviridae, order Nidovirales [45]. |
