LitCovid-sentences  

PMC:7352545 / 24580-26133 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T233 0-6 Sentence denotes 4.2.2.
T234 7-34 Sentence denotes SA C9-O-Acetyl Modification
T235 35-213 Sentence denotes The SA 9-O-acetylation in hosts allows hosts to evade influenza A virus hemagglutinin (HA) recognition and some lectins of factor H (FH), CD22/Siglec-2 and sialoadhesin/Siglec-1.
T236 214-343 Sentence denotes Instead, the influenza C virus HA recognizes the hosts. β-elimination and permethylation eliminate the 9-O-acetyl group from SAs.
T237 344-586 Sentence denotes Chemical modification of the C-9 position of Neu5,9Ac2 generates a 9-N-acetyl analog, 9-acetamido-9-deoxy-N-acetylneuraminic acid (Neu5Ac9NAc), a mimic of Neu5,9Ac2 with influenza C virus-binding capacity, which is not cleaved by the HE [42].
T238 587-653 Sentence denotes SA O-acetylesterase regulates the presence of 7,9-O-Ac and 9-O-Ac.
T239 654-740 Sentence denotes SA O-acetylation and deacetylation are involved in development, cancer and immunology.
T240 741-807 Sentence denotes SA O-acetylation alters host lectin bindings such as siglecs [29].
T241 808-872 Sentence denotes The presence of 9-O-Ac can also reduce the activity of NAs [43].
T242 873-932 Sentence denotes SA modifications regulate pathogen binding or pathogen NAs.
T243 933-991 Sentence denotes Influenza A/B/C/D viruses use SA as their entry receptors.
T244 992-1127 Sentence denotes Influenza A and B subtypes bind to SAs via HA and NA to allow endocytosis of the virus and fusion of the viral envelope with endosomes.
T245 1128-1238 Sentence denotes In contrast, influenza C and D subtypes bear only one coated glycoprotein, termed the HE fusion protein (HEF).
T246 1239-1269 Sentence denotes The HEF acts as the HA and NA.
T247 1270-1457 Sentence denotes HEF recognizes 9-O-acetyl SA for entry into cells, while the esterase domain removes 9-O-acetyl-groups and liberates the virus from mucus and mis-assembled virus aggregates after budding.
T248 1458-1553 Sentence denotes The 9-O-Ac on cells prevents the NA activity and HA binding of the influenza A type virus [44].