LitCovid-sentences  

PMC:7352545 / 23215-24578 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T221 0-139 Sentence denotes The position of SA O-acetylation is linked to functions including substrate differentiation of enzymes such as NAs and esterase by C4 O-Ac.
T222 140-269 Sentence denotes Previous development of O-Ac site-selective NA inhibitors were based on the conceptual consideration of different O-Ac positions.
T223 270-378 Sentence denotes The O-Ac of SAs is site-specific, as C4 of Neu5Ac is considered to be a potential position for modification.
T224 379-487 Sentence denotes Historically, inhibitors of influenza A and B viruses-sialidases were designed by Von-Itzstein in 1993 [39].
T225 488-597 Sentence denotes The Ac group-based C4 substitution interacts with amino acid Glu-119 present in the active site of sialidase.
T226 598-767 Sentence denotes Guanidine-attached C4 of C2–C3 unsaturated SA (Neu5Ac2en) inhibits activity of sialidases isolated from influenza A virus (Singapore/1/57) and B virus (Victoria/102/85).
T227 768-902 Sentence denotes The same scenario was applied for sialidase inhibition of the human parainfluenza virus type 3, which has HN and fusion proteins [40].
T228 903-981 Sentence denotes The C4 of Neu5Ac2en was substituted by alkyl groups such as the O-ethyl group.
T229 982-1071 Sentence denotes For example, Zanamivir has a substitution with a 4-guanidino group with an IC50 of 25 μM.
T230 1072-1145 Sentence denotes Thus, sialidase inhibition is important for C4 modification of Neu5Ac2en.
T231 1146-1289 Sentence denotes Later, oseltamivir with the tradename Tamiflu (Basel, Switzerland) and zanamivir with the tradename Relenza (London, UK) were established [41].
T232 1290-1363 Sentence denotes These drugs exhibit some adverse side effects that restrict clinical use.