LitCovid-sentences  

PMC:7352545 / 22115-24578 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T211 0-6 Sentence denotes 4.2.1.
T212 7-31 Sentence denotes C4-O-Acetyl Modification
T213 32-146 Sentence denotes For example, in the horse, C4-O-acetyl modification of Neu5Ac (SA) occupies more than 50% of the total SA content.
T214 147-221 Sentence denotes The C4-O-acetylated Neu5Ac, Neu4,5Ac2, inhibits the influenza A2 virus HA.
T215 222-359 Sentence denotes De-acetylation reagents such as NaOH or NaIO4 treatment completely hemagglutinate Neu4,5Ac2 by elimination of the C4-O-acetyl group [33].
T216 360-497 Sentence denotes The C4-O-acetyl Neu5Ac species are found in various sources such as equine erythrocyte GM3, starfish A. rubens and fish [34,35,36,37,38].
T217 498-583 Sentence denotes C4-O-acetylated Neu5Ac facilitates the initial attachment of viruses to target cells.
T218 584-753 Sentence denotes Like the influenza C virus, infectious salmon anemia virus (ISAV), a member of the Orthomyxoviridae family, contains HE and HEF proteins to mediate virus entry and exit.
T219 754-907 Sentence denotes C4-O-Ac Neu5Ac is the major receptor determinant of ISAV in receptor binding and destruction [38], while the influenza C virus recognizes C9-O-Ac Neu5Ac.
T220 908-1099 Sentence denotes The acetylesterase RDE of ISAV cleaves C4-O-Ac via 4-SA-O-acetylesterase with a short turnover time, whereas C9-O-Ac Neu5Ac is cleaved by 9-SA-O-acetylesterase with a long turnover time [34].
T221 1100-1239 Sentence denotes The position of SA O-acetylation is linked to functions including substrate differentiation of enzymes such as NAs and esterase by C4 O-Ac.
T222 1240-1369 Sentence denotes Previous development of O-Ac site-selective NA inhibitors were based on the conceptual consideration of different O-Ac positions.
T223 1370-1478 Sentence denotes The O-Ac of SAs is site-specific, as C4 of Neu5Ac is considered to be a potential position for modification.
T224 1479-1587 Sentence denotes Historically, inhibitors of influenza A and B viruses-sialidases were designed by Von-Itzstein in 1993 [39].
T225 1588-1697 Sentence denotes The Ac group-based C4 substitution interacts with amino acid Glu-119 present in the active site of sialidase.
T226 1698-1867 Sentence denotes Guanidine-attached C4 of C2–C3 unsaturated SA (Neu5Ac2en) inhibits activity of sialidases isolated from influenza A virus (Singapore/1/57) and B virus (Victoria/102/85).
T227 1868-2002 Sentence denotes The same scenario was applied for sialidase inhibition of the human parainfluenza virus type 3, which has HN and fusion proteins [40].
T228 2003-2081 Sentence denotes The C4 of Neu5Ac2en was substituted by alkyl groups such as the O-ethyl group.
T229 2082-2171 Sentence denotes For example, Zanamivir has a substitution with a 4-guanidino group with an IC50 of 25 μM.
T230 2172-2245 Sentence denotes Thus, sialidase inhibition is important for C4 modification of Neu5Ac2en.
T231 2246-2389 Sentence denotes Later, oseltamivir with the tradename Tamiflu (Basel, Switzerland) and zanamivir with the tradename Relenza (London, UK) were established [41].
T232 2390-2463 Sentence denotes These drugs exhibit some adverse side effects that restrict clinical use.