PMC:7352545 / 15731-16749 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T140 0-4 Sentence denotes 3.2.
T141 5-29 Sentence denotes Nucleocapsid (N) Protein
T142 30-92 Sentence denotes In RNA viruses, the N protein recognizes the viral RNA genome.
T143 93-112 Sentence denotes The N protein (PDB:
T144 113-163 Sentence denotes 6M3M) binds to the RNA genome via the NTD and CTD.
T145 164-245 Sentence denotes The N protein tethers to the viral RNA and replicase–transcriptase complex (RTC).
T146 246-256 Sentence denotes NSP3 (PDB:
T147 257-314 Sentence denotes 6VXS) of CoV blocks the innate immune responses of hosts.
T148 315-497 Sentence denotes After entrance into the host cells, for CoV transcription and particle release, RNA chaperones such as nonspecific nucleic acid binding proteins potentiate ssRNA conformation shifts.
T149 498-568 Sentence denotes Representatively, the N protein is known as the RNA chaperone protein.
T150 569-741 Sentence denotes For example, glycogen synthase kinase 3 (GSK3) phosphorylates the SARS-CoV N-protein and thus, GSK3 inhibition contributes to reduced replication activity of SARS-CoV [19].
T151 742-1018 Sentence denotes In addition, heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) regulates the preformed mRNA splicing in the nucleus and continuous translation. hnRNPA1 interacts with SARS-CoV N protein to form a replication and transcription complex during ssRNA genome biosynthesis [20].