| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T23 |
0-176 |
Sentence |
denotes |
Dissecting the complex pathogenesis of CAPA requires a molecular understanding of the physiological processes whereby infection with SARS-CoV-2 facilitates fungal pathogenesis. |
| T24 |
177-389 |
Sentence |
denotes |
Similar to other SARS coronaviruses, SARS-CoV-2 targets and invades epithelial cells and type II pneumocytes through binding of the SARS spike protein to the angiotensin-converting enzyme 2 (ACE2) receptors [11]. |
| T25 |
390-578 |
Sentence |
denotes |
Cleavage of the S1/S2 domain by the type 2 transmembrane protease TMPRSS2 leads to the activation of the spike protein [12], thereby facilitating viral entry into the target cell via ACE2. |
| T26 |
579-722 |
Sentence |
denotes |
Besides its role as a SARS virus receptor, ACE2 was also demonstrated to be required for protection from severe acute lung injury in ARDS [13]. |
| T27 |
723-861 |
Sentence |
denotes |
In support of this, an insertion/deletion polymorphism that affects ACE activity was associated with ARDS susceptibility and outcome [14]. |
| T28 |
862-1077 |
Sentence |
denotes |
Whether the preceding interaction of SARS-CoV-2 with host cells, by disrupting the regulation of the renin-angiotensin system and or the kallikrein-kinin system, contributes to the development of CAPA, is not known. |
