| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T134 |
0-2 |
Sentence |
denotes |
7. |
| T135 |
3-48 |
Sentence |
denotes |
The Current Challenges and How to Tackle Them |
| T136 |
49-132 |
Sentence |
denotes |
Bacterial, fungal and viral secondary infections or co-infections affect mortality. |
| T137 |
133-274 |
Sentence |
denotes |
Acinetobacter baumanii, Klebsiella pneumonia and Aspergillus species are important nosocomial pathogens [93] complicating the disease course. |
| T138 |
275-382 |
Sentence |
denotes |
Studies from France [51], Germany [50], Belgium [52], and the Netherlands [47], underline the role of CAPA. |
| T139 |
383-481 |
Sentence |
denotes |
Diagnosing co-infections is complex and rapid diagnosis plays a crucial role in this setting [49]. |
| T140 |
482-650 |
Sentence |
denotes |
Close monitoring for infection development is needed, as well as longitudinal sampling throughout the disease course using culture dependent and independent techniques. |
| T141 |
651-821 |
Sentence |
denotes |
Aspergillus antigen and PCR testing of respiratory fluids should be a routine procedure for critically ill patients [94], specifically for those suffering from ARDS [50]. |
| T142 |
822-932 |
Sentence |
denotes |
Co-infection with human metapneumovirus has been reported in two of five cases in the German CAPA series [50]. |
| T143 |
933-1121 |
Sentence |
denotes |
It is unknown whether hospitals caring for COVID-19 test comprehensive respiratory pathogen panels, and to date no analysis of mixed viral infection in COVID-19 patients has been reported. |
| T144 |
1122-1259 |
Sentence |
denotes |
In the context of COVID-19, mixed viral infection may be misinterpreted as presence of innocent bystanders and thus remain underreported. |
| T145 |
1260-1373 |
Sentence |
denotes |
With bronchoalveolar lavage and autopsy regarded as high-risk procedures, key diagnostic instruments are lacking. |
| T146 |
1374-1532 |
Sentence |
denotes |
Autopsy studies are key to understanding pathophysiology of COVID-19 [95] and are critically enlighten interaction between SARS-CoV-2 and different pathogens. |
| T147 |
1533-1689 |
Sentence |
denotes |
With availability of lower respiratory samples, normally obtained by BALF, the quality of microbiological and virological work up would be greatly improved. |
| T148 |
1690-1818 |
Sentence |
denotes |
Inspection of trachea and bronchi is achieved by bronchoscopy, which is critical to find possible Aspergillus tracheobronchitis. |
| T149 |
1819-2040 |
Sentence |
denotes |
Thus, physicians face the dilemma of taking the hazard of aerosolization of SARS-CoV-2, risking transmission versus the endeavor of facilitating the optimal diagnosis and treatment to the patients entrusted to their care. |
| T150 |
2041-2150 |
Sentence |
denotes |
To this day, our understanding of the true impact of Aspergillus co-infections remains frustratingly limited. |
| T151 |
2151-2290 |
Sentence |
denotes |
Therefore, guidance on proper management of these high-risk procedures to prevent transmission and super spreading of SARS-CoV-2 is needed. |
| T152 |
2291-2510 |
Sentence |
denotes |
The European Confederation of Medical Mycology initiated national multicenter studies aiming to explore the risk of fungal infections during COVID-19 [94] and is currently working on diagnostic and treatment algorithms. |
| T153 |
2511-2634 |
Sentence |
denotes |
Key goals are to improve the outcome by avoiding misdiagnosis and by initiation of early and targeted antifungal treatment. |
