LitCovid-sentences  

PMC:7344504 / 2043-9126 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T18 0-2 Sentence denotes 2.
T19 3-26 Sentence denotes Case Report and Results
T20 27-124 Sentence denotes A 74-year-old patient was admitted because of respiratory insufficiency amid the COVID-19 crisis.
T21 125-217 Sentence denotes Eleven days prior to admission, she had been suffering from fever (38.5 °C) and a dry cough.
T22 218-273 Sentence denotes Three days after symptom onset, she developed diarrhea.
T23 274-498 Sentence denotes Her medical history included complaints of reflux and pain due to arthrosis of the hip and knees, for which she uses a proton-pump inhibitor and a nonsteroidal anti-inflammatory drug pantoprazol and etoricoxib, respectively.
T24 499-566 Sentence denotes She stopped smoking 20 years ago and was healthy and fit otherwise.
T25 567-615 Sentence denotes Patient characteristics can be found in Table 1.
T26 616-899 Sentence denotes This study, “Clinical course and prognostic factors for COVID-19” with project identification code CWZ-nr 027-2020, was approved in March 20202 by the Canisius Wilhelmina Hospital medical ethics committee and patient informed consent was acquired antemortem with opt out possibility.
T27 900-1002 Sentence denotes At presentation to the emergency department, she had been feeling progressively dyspneic for two days.
T28 1003-1139 Sentence denotes On physical examination, her oxygenation was 82%, with 28 breaths per minute in room air, pulmonary wheezing and an extended expiration.
T29 1140-1235 Sentence denotes Oxygenation improved to 94% with 5 L O2 via a nasal cannula, but she desaturated during speech.
T30 1236-1289 Sentence denotes Her BMI was 27.7 (80 kg) and her temperature 37.8 °C.
T31 1290-1355 Sentence denotes No other aberrant observations on physical examination were made.
T32 1356-1409 Sentence denotes Her Glasgow Coma Scale was 15 and her ECG was normal.
T33 1410-1839 Sentence denotes Her C-reactive protein (CRP) was 214 mg/L, and other laboratory findings included slightly elevated leucocytes (12.6 × 109 /L) and neutrophils (8.4 × 109 /L), elevated liver enzymes (alkaline phosphatase 528 U/L; GGT 376 U/L; AST 76 U/L; LD 745 U/L), slightly elevated pro-calcitonin (0.25 µg/L; <0.5 µg/L not suggestive of bacterial infection), increased ferritin (1442 µg/L), and normal electrolyte, glucose and renal function.
T34 1840-1894 Sentence denotes SARS-CoV-2 nasopharyngeal and throat swabs were taken.
T35 1895-2120 Sentence denotes A low-dose chest CT demonstrated extensive centralized and peripheral bilateral ground glass opacities with left-sided consolidations and bilateral fibrotic bands without pleural effusions and vascular enlargement (Figure 1).
T36 2121-2189 Sentence denotes The CO-RADS score was 5 and CT-severity score was 24 out of 25 [11].
T37 2190-2371 Sentence denotes Because of the high probability of SARS-CoV-2 infection, chloroquine treatment was started (600 mg and 300 mg on day 1, 300 mg q12h days 2–5), which was national policy at the time.
T38 2372-2453 Sentence denotes The SARS-CoV-2 PCR of a nasopharyngeal swab was positive (Ct 30.59; E gene [12]).
T39 2454-2546 Sentence denotes Blood cultures remained negative, as were nasopharynx bacterial cultures taken at admission.
T40 2547-2627 Sentence denotes The patient was subsequently admitted to our general inpatient respiratory ward.
T41 2628-2687 Sentence denotes An overview of her hospital course is depicted in Figure 2.
T42 2688-2786 Sentence denotes The CRP remained highly stable over the following days at around 200 mg/L with a range of 192–214.
T43 2787-2866 Sentence denotes However, the patient needed increasing oxygenation with a non-rebreathing mask.
T44 2867-2960 Sentence denotes Empirical treatment of a suspected bacterial superinfection was started with ceftriaxone i.v.
T45 2961-2974 Sentence denotes 2000 mg q24h.
T46 2975-3175 Sentence denotes Five days after admission, the maximum (15 L O2) oxygenation with the non-rebreathing mask became insufficient and the patient was admitted to the ICU for respiratory support and intensive monitoring.
T47 3176-3319 Sentence denotes In the ICU, HFNO (high-flow nasal oxygen therapy) and selective digestive decontamination (SDD) were initiated, which includes ceftriaxone i.v.
T48 3320-3437 Sentence denotes 2000 mg q24h for 4 days and a combined oral non-absorbable suspension of amphotericin B, colistin and tobramycin q6h.
T49 3438-3509 Sentence denotes In this patient, ceftriaxone was continued de facto for another 4 days.
T50 3510-3670 Sentence denotes Routine bacterial and fungal (peri-anal, throat and tracheal aspirate) surveillance cultures were done twice weekly in adherence with our local SDD policy [13].
T51 3671-3801 Sentence denotes Within a few hours after admission to the ICU, her blood oxygenation became insufficient with HFNO at FiO2 100% and 60 L/min flow.
T52 3802-3875 Sentence denotes Therefore, she was sedated, intubated and put on a mechanical ventilator.
T53 3876-3978 Sentence denotes A CT angiography of the chest was performed which demonstrated significant bilateral pulmonary emboli.
T54 3979-4061 Sentence denotes Anticoagulants (enoxaparine anti-factor Xa) were initiated in therapeutic dosages.
T55 4062-4139 Sentence denotes Pressure control ventilation was required with the patient in prone position.
T56 4140-4291 Sentence denotes Because of the need for increasing noradrenaline dosages during circulatory shock, hydrocortisone 100 mg q8h was initiated and continued for five days.
T57 4292-4373 Sentence denotes Cardiac ultrasound showed a minor tricuspid insufficiency but no major pathology.
T58 4374-4485 Sentence denotes Aspergillus fumigatus was recovered from high-volume tracheal aspirate cultures [14] obtained at ICU admission.
T59 4486-4806 Sentence denotes Aspergillus galactomannan (Platelia Aspergillus; Bio-Rad, Marnes-La-Coquette, France) ratio at this time was >3.0 (positive) in a tracheal aspirate and β-d-glucan (Fungitell assay; Associates of Cape Cod Inc., East Falmouth, MA, USA) in serum was 1590 pg/mL (positive), after which a putative diagnosis of CAPA was made.
T60 4807-4880 Sentence denotes Serum galactomannan remained negative (<0.5) in three subsequent samples.
T61 4881-4898 Sentence denotes Voriconazole i.v.
T62 4899-4955 Sentence denotes 6 mg/kg q12h was started in addition to caspofungin i.v.
T63 4956-5080 Sentence denotes 70 mg q24h until the VIPcheck (Mediaproducts BV, Groningen, The Netherlands), used to detect azole resistance, was negative.
T64 5081-5330 Sentence denotes MICs determined with broth microdilution using CLSI methodology of the A. fumigatus isolate were as follows: amphotericin B 0.5 mg/L, micafungin and anidulafungin <0.016 mg/L, itraconazole 1 mg/L, voriconazole 0.25 mg/L, and posaconazole 0.063 mg/L.
T65 5331-5431 Sentence denotes Voriconazole was switched to oral administration of 200 mg q12h with discontinuation of caspofungin.
T66 5432-5512 Sentence denotes During SDD, bacterial cultures remained negative throughout her stay in the ICU.
T67 5513-5660 Sentence denotes On day 6 after admission (day 2 at the ICU), continuous venovenous hemofiltration was initiated because of rapidly progressive acute renal failure.
T68 5661-5921 Sentence denotes A. fumigatus was persistently cultured from tracheal aspirate samples during voriconazole treatment and β-d-glucan levels remained positive with 1149 and 1458 pg/µl, at 1 and 6 days (day 8 and 13 after hospital admission) of voriconazole therapy, respectively.
T69 5922-6109 Sentence denotes Voriconazole serum therapeutic drug monitoring was performed as recommended [15], with therapeutic concentrations of 4.72 mg/L, 2.78 mg/L and 1.43 mg/L at day 13, 15 and 17, respectively.
T70 6110-6214 Sentence denotes The respiratory situation improved marginally in the subsequent 7 days but declined steadily thereafter.
T71 6215-6381 Sentence denotes Pressure support and pressure control ventilation were alternated between days 12 and 19 and attempts to return the patient to a supine position failed several times.
T72 6382-6518 Sentence denotes After 7 days, A. fumigatus grew on the itraconazole and voriconazole wells of the second VIPcheck on day 19 (tracheal aspirate culture).
T73 6519-6705 Sentence denotes MICs of this A. fumigatus isolate were as follows: amphotericin B 0.5 mg/L, anidulafungin and micafungin <0.016 mg/L, itraconazole 16 mg/L, voriconazole 2 mg/L and posaconazole 0.5 mg/L.
T74 6706-6781 Sentence denotes Voriconazole treatment was changed to liposomal amphotericin B 200 mg q24h.
T75 6782-6904 Sentence denotes Subsequent cyp51A gene sequencing identified a TR34/L98H mutation, probably responsible for the observed azole resistance.
T76 6905-7053 Sentence denotes On day 22, ventilation and oxygenation of the patient deteriorated further without further treatment options and therapy was discontinued on day 23.
T77 7054-7083 Sentence denotes An autopsy was not performed.