LitCovid-sentences  

PMC:7341831 / 7403-11327 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T72 0-10 Sentence denotes DISCUSSION
T73 11-199 Sentence denotes Our report illustrates the importance of considering IPA in patients with underlying severe COVID-19, who show no clear clinical impairment related to IPA throughout their hospitalization.
T74 200-353 Sentence denotes In this case, the patient was likely immunologically compromised due to his underlying conditions (Type II diabetes mellitus and chronic kidney disease).
T75 354-592 Sentence denotes This case underscores the need to investigate this neglected disease and allow for early tracing with antifungal treatment; however, it is necessary to consider the risks posed by the bronchoscopy that must be performed for the diagnosis.
T76 593-608 Sentence denotes Antinori et al.
T77 609-909 Sentence denotes 8 assessed the postmortem lung examination of a patient with IPA and COVID-19, in which IPA was characterized by bronchial wall ulceration associated with multiple spots of necrotizing pneumonia, and the residual lung parenchyma displayed a pattern of acute lung injury with diffuse alveolar damage.
T78 910-1089 Sentence denotes In addition to the presence of bronchopneumonia, we distinctly show fungi (hyphae and conidia) within blood vessels, the hallmark of the invasive disease triggered by this fungus.
T79 1090-1239 Sentence denotes The presence of GM in bronchoalveolar lavage is a useful marker, but this procedure is not performed in many COVID-19 patients for biosafety reasons.
T80 1240-1460 Sentence denotes However, the identification of this antigen in peripheral blood, a test that is usually negative, is seemingly a reliable marker of invasive disease, especially in our case, in which the invasion of vessels was observed.
T81 1461-1707 Sentence denotes In addition, it is important to consider that the use of medications, such as oseltamivir, which is preemptively prescribed for influenza infection, may potentially block host neuraminidase, thus increasing patient susceptibility to IPA 5 , 6 .
T82 1708-1830 Sentence denotes The use of corticosteroids, which is still a matter of debate in COVID-19 treatment, may also facilitate invasive disease.
T83 1831-1939 Sentence denotes Therefore, we recommend caution in the use of corticosteroids and oseltamivir to treat SARS-CoV-2 infection.
T84 1940-2042 Sentence denotes Meanwhile, chloroquine has been proposed as a drug with antifungal and immune response properties 11 .
T85 2043-2226 Sentence denotes As the patient clinical status was already critical upon his arrival and he died three days after hospitalization, the possibility of a hospital-acquired fungal infection is unlikely.
T86 2227-2421 Sentence denotes It is possible that aspergillosis could predispose patients with COVID-19 to clinical worsening, and it is therefore necessary to further assess this two-way interaction between both infections.
T87 2422-2558 Sentence denotes A. penicillioides is a xerophilic species occurring in dry habitats and in house dust; it is responsible for human and animal allergies.
T88 2559-2677 Sentence denotes Dry oxygen supplementation intended to prevent aerosolization could explain the infection caused by this pathogen 12 .
T89 2678-2783 Sentence denotes To the best of our knowledge, this is the fourth clinical report on A. penicillioides clinical infection.
T90 2784-2938 Sentence denotes The other three are classified as keratitis, disseminated disease in a child with cystic fibrosis, and central nervous system arteritis 13 , 14 , 15 .
T91 2939-3050 Sentence denotes No information is available on the antifungal sensitivity of this species or the frequency of invasive disease.
T92 3051-3150 Sentence denotes In conclusion, we report a case of IPA in a patient with severe pneumonia associated with COVID-19.
T93 3151-3353 Sentence denotes Using a gold standard method (histopathology) in our case series, the frequency of IPA was lower, as compared to that of cases published elsewhere; possible overestimation might be due to contamination.
T94 3354-3547 Sentence denotes In our case, no CT imaging of the lung, sequential GM, or culture for fungus was performed, thus reinforcing the role of autopsies as a form of postmortem surveillance of such a severe disease.
T95 3548-3751 Sentence denotes As the outbreak of COVID-19 continues to spread around the world, further reports are needed to assess the occurrence and frequency of IPA in severe SARS-CoV-2 infections, and their clinical interaction.
T96 3752-3924 Sentence denotes These studies are needed to assess the incidence of IPA and define at-risk populations, thus offering a strategy for diagnosis, prophylaxis, and timely clinical management.