LitCovid-sentences  

PMC:7340597 / 6542-12573 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T56 0-22 Sentence denotes 3.1 Clinical features
T57 23-116 Sentence denotes During the study period, seven patients underwent postmortem needle core biopsy of the lungs.
T58 117-202 Sentence denotes Patients age ranged from 58 to 83 years (median 74 year) and five patients were male.
T59 203-269 Sentence denotes None of the patients had a history of (chronic) pulmonary disease.
T60 270-387 Sentence denotes One patient used immunosuppressive medication before hospital admission, in this case a short course of prednisolone.
T61 388-468 Sentence denotes Median time from hospital to ICU admission was 0 days (interquartile range 0–4).
T62 469-533 Sentence denotes Time from hospital admission to death ranged from 12 to 36 days.
T63 534-596 Sentence denotes Patients deceased at median of 21(range 9–36) ventilated days.
T64 597-674 Sentence denotes In five out of seven patients ICU stay was complicated by pulmonary embolism.
T65 675-842 Sentence denotes Adopting the proposed definition of CAPA by van Arkel et al. [9], six patients were classified as having probable CAPA (Table 1 ), based on a positive GM on BAL fluid.
T66 843-941 Sentence denotes In those patients, combination antifungal therapy with voriconazole and anidulafungin was started.
T67 942-1093 Sentence denotes Three out of six patients were on corticosteroids (60 mg prednisolone daily) at the time of CAPA diagnosis and corticosteroid treatment was terminated.
T68 1094-1236 Sentence denotes Indication for steroid treatment in these patients was a suspicion of an organizing pneumonia on chest CT or signs of progression to fibrosis.
T69 1237-1379 Sentence denotes Nosocomial infections including signs for pulmonary aspergillosis were excluded by bronchoscopy with BAL before steroid treatment was started.
T70 1380-1501 Sentence denotes Radiologic findings of chest CT and histologic results of the lungs biopsies of all seven patients are shown in Table 2 .
T71 1502-1554 Sentence denotes Table 1 Patient characteristics and clinical course.
T72 1555-1839 Sentence denotes Case Sex, age (years) Medical history Total hospital days Total ventilated days Berlin classification of ARDS Compliance phenotype PE BAL fluid GM and culture (days post hospital admission) CAPA Chloroquine Prednisolone use during hospital admission Duration of prednisolone treatment
T73 1840-1895 Sentence denotes 1 M, 77 None 12 10 Severe Low Yes GM negative No Yes No
T74 1896-1997 Sentence denotes 2 F, 73 None 20 16 Severe High Yes GM index 4.4 (day 19) Aspergillus fumigatus Probable No Yes 8 days
T75 1998-2077 Sentence denotes 3 F, 58 None 30 26 Severe Low Yes GM index 3.4 (day 20) Probable Yes Yes 5 days
T76 2078-2193 Sentence denotes 4 M, 68 None 21 21 Moderate Low Yes GM index 5.7 (day 1) Aspergillus fumigatus Enterococcus faecium Probable Yes No
T77 2194-2298 Sentence denotes 5 M, 78 HT, CKI 22 21 Moderate Low No GM index 4.3 (day 20) Enterococcus faecium Probable Yes Yes 2 days
T78 2299-2372 Sentence denotes 6 M, 83 HT, DM 13 9 Moderate Low No GM index 1.7 (day 11) Probable Yes No
T79 2373-2474 Sentence denotes 7 M, 74 None 36 36 Severe Low Yes GM index 4.4 (day 24) Enterococcus faecalis Probable Yes Yes 4 days
T80 2475-2707 Sentence denotes ARDS acute respiratory distress syndrome; BAL broncho-alveolar lavage; CAPA, COVID-19 associated pulmonary aspergillosis; CKI, chronic kidney injury; DM, diabetes mellitus; GM, galactomannan; HT, hypertension; PE pulmonary embolism.
T81 2708-2769 Sentence denotes Table 2 Radiological Chest CT scan and histological findings.
T82 2770-2840 Sentence denotes Case Radiological findings Histological findings description Diagnosis
T83 2841-3131 Sentence denotes 1 GGO, crazy paving, non-dependent consolidation, subpleural sparing, segmental and subsegmental PE Intra-alveolar fibromyxoid/fibroblastic bodies (25%), micro-thrombi, thrombi in lager vessels, hyperplasia with atypia, multinucleated giant cell, intranuclear inclusion bodies, no hyphae OP
T84 3132-3385 Sentence denotes 2 GGO, crazy paving, resolving consolidation, bronchiectasis, segmental and subsegmental PE Extensive fibrosis with destruction of alveolar structures, hyperplasia with atypia, multinucleated giant cell, intranuclear inclusion bodies, no hyphae Fibrosis
T85 3386-3654 Sentence denotes 3 GGO, large dependent consolidation, bronchiectasis, subsegmental PE Inflammatory infiltrate, hyaline membranes, sporadic intra-alveolar fibroblastic plug, micro-thrombi, hyperplasia with atypia, multinucleated giant cell, intranuclear inclusion bodies, no hyphae DAD
T86 3655-3974 Sentence denotes 4 GGO, crazy paving, non-dependent consolidation, bronchiectasis, segmental and subsegmental PE Intra-alveolar fibroblastic tissue, with a diffuse component of fibrinous exudate, widening of alveolar septa, micro-thrombi, hyperplasia with atypia, multinucleated giant cell, intranuclear inclusion bodies, no hyphae AFOP
T87 3975-4160 Sentence denotes 5 GGO, consolidation Intra-alveolar fibromyxoid/fibroblastic bodies (32%), micro-thrombi, hyperplasia with atypia, multinucleated giant cell, intranuclear inclusion bodies, no hyphae OP
T88 4161-4374 Sentence denotes 6 GGO, consolidation Intra-alveolar fibromyxoid/fibroblastic bodies (80%), widening of alveolar septa, micro-thrombi, hyperplasia with atypia, multinucleated giant cell, intranuclear inclusion bodies, no hyphae OP
T89 4375-4640 Sentence denotes 7 GGO, crazy paving, consolidation, bronchiectasis, subsegmental PE Intra-alveolar fibromyxoid/fibroblastic bodies (27%), mild widening of alveolar septa, micro-thrombi, hyperplasia with atypia, multinucleated giant cell, intranuclear inclusion bodies, no hyphae OP
T90 4641-4793 Sentence denotes AFOP acute fibrinous and organizing pneumonia, DAD diffuse alveolar damage, GGO, ground glass opacities; OP organizing pneumonia; PE pulmonary embolism.
T91 4794-4957 Sentence denotes To further investigate histopathologic findings we now present the detailed clinical course of four patients with four different histopathological characteristics.
T92 4958-5134 Sentence denotes Because of complexity and importance of the distinct patterns and their relation with radiologic findings and treatment, we preferred to discuss them separately in more detail.
T93 5135-5204 Sentence denotes Chest CT imaging of the four discussed patients are shown in Fig. 1 .
T94 5205-5239 Sentence denotes Fig. 1 Chest CT scans of case 1–4.
T95 5240-5378 Sentence denotes For each patient image A represents chest CT at hospital admission, image B follow up CT-scan (note: chest CT of case 4 was not repeated).
T96 5379-5526 Sentence denotes 1A: bilateral areas of GGO, patchy subpleural non-dependant consolidations 1B: progression of dens subpleural consolidations with air-bronchograms.
T97 5527-5637 Sentence denotes 2A GGO in both lungs, combined with crazy-paving pattern, subtle bronchiectasis are present in affected areas.
T98 5638-5762 Sentence denotes 2B GGO persisted, without progression to consolidations, more pronounced fibrotic reticulation with traction bronchiectasis.
T99 5763-5832 Sentence denotes 3A diffuse bilateral GGO with large gravity dependant consolidations.
T100 5833-5931 Sentence denotes 3B persistent GGO and consolidation, newly formed cyst-like lesions in middle and ventral regions.
T101 5932-6031 Sentence denotes 4A bilateral areas of GGO, patchy non-dependant peripheral consolidations with mild bronchiectasis.