| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T213 |
0-209 |
Sentence |
denotes |
Recently there is increasing awareness and concern for development of secondary infection in COVID patients e.g. invasive aspergillus co-infection, a contra-indication for (long-term) systemic steroid therapy. |
| T214 |
210-323 |
Sentence |
denotes |
Criteria and risk factors for invasive pulmonary aspergillosis are well defined in immunocompromised populations. |
| T215 |
324-534 |
Sentence |
denotes |
Furthermore it is a well known complication of severe influenza pneumonia with reported incidences of 19% in ICU patients admitted for influenza related acute respiratory failure with high mortality rates [33]. |
| T216 |
535-723 |
Sentence |
denotes |
In COVID-19 associated pulmonary aspergillosis (CAPA) case definition is absent, although recently an expert panel proposed a classification for IAPA, which was used to classify CAPA [14]. |
| T217 |
724-936 |
Sentence |
denotes |
Pathophysiology of CAPA consists of lung damage with bilateral alveolar-interstitial damage due to viral replication and cytokine storm in combination with marked low T-lymphocytes CD4 + T and CD8 + T cells [27]. |
| T218 |
937-1023 |
Sentence |
denotes |
Secondary infection due to lung tissue damage develop within a median of 17 days [34]. |
| T219 |
1024-1136 |
Sentence |
denotes |
CAPA data are scarce but increasingly reported, although histological confirmation is still absent [9,13,35,36]. |
| T220 |
1137-1278 |
Sentence |
denotes |
Of the first 31 COVID-19 patients admitted to our ICU, six where highly suspected for COVID-19 associated pulmonary aspergillosis (CAPA) [9]. |
| T221 |
1279-1422 |
Sentence |
denotes |
In this case series, BAL fluid galactomannan was positive in six out of the seven cases, concluding in the clinical diagnosis of probable CAPA. |
