| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T196 |
0-124 |
Sentence |
denotes |
Although the exact pathogenesis of OP remains unknown, it is thought that OP is a consequence of alveolar epithelial injury. |
| T197 |
125-269 |
Sentence |
denotes |
This initial epithelial injury is followed by leakage of plasma proteins, leading to a cascade of host responses with hyperinflammation [27,28]. |
| T198 |
270-388 |
Sentence |
denotes |
Subsequent fibroblast recruitment and connective tissue and fibroblast organisation is seen within the alveolar space. |
| T199 |
389-606 |
Sentence |
denotes |
Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) play a central role in organizing pneumonia and are highly expressed in intraluminal fibromyxoid lesion in organizing pneumonia [29]. |
| T200 |
607-778 |
Sentence |
denotes |
Interestingly, binding to ACE2 receptor is recognized as a critical initial step for SARS-CoV-2 to entry alveolar type II cells, resulting in loss of ACE2 at the membrane. |
| T201 |
779-899 |
Sentence |
denotes |
ACE 2 is a negative regulator of the renin-angiotensin system (RAS) and this depletion of ACE2 upregulates the RAS [30]. |
| T202 |
900-955 |
Sentence |
denotes |
An activated RAS can induce Fibroblastic Growth Factor. |
| T203 |
956-1017 |
Sentence |
denotes |
ACE2 also plays a role in regulating the effect of VEGF [31]. |
| T204 |
1018-1172 |
Sentence |
denotes |
Therefore, depletion of ACE2 due to the high affinity of SARS-CO-V2 to ACE2 might play a role in the pathogenesis of COVID19 related organizing pneumonia. |
