LitCovid-sentences  

PMC:7335644 / 53-2641 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3 0-12 Sentence denotes Dear Editor:
T4 13-61 Sentence denotes We appreciate the comment from Hemilä et al [1].
T5 62-201 Sentence denotes Previous studies based on in-vitro experiments have identified that high dosage intravenous Vit-C with copper and/or iron is virucidal [2].
T6 202-307 Sentence denotes However, despite these studies, the in-vivo virucidal activity of Vit-C has not been confirmed in detail.
T7 308-447 Sentence denotes Previously, your meta-analyses of clinical trial data showed that regular Vit-C intake shortened the duration of the common cold by 8% [3].
T8 448-665 Sentence denotes However, coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus (severe acute respiratory syndrome coronavirus 2) whose genome sequence differs from other human coronaviruses causing the common cold [4].
T9 666-849 Sentence denotes Moreover, two recent clinical trials have demonstrated no significant difference in the development of sepsis, or severe acute respiratory failure, between Vit-C and non-Vit-C groups.
T10 850-1019 Sentence denotes In the CITRIS-ALI trial, no significant difference was found between the Vit-C (50 mg/kg every 6 hours for 96 hours) and placebo groups in the primary outcomes measured.
T11 1020-1153 Sentence denotes These included modified Sequential Organ Failure Assessment score, C-reactive protein levels, and thrombomodulin levels at 168 hours.
T12 1154-1379 Sentence denotes However, secondary outcome measures did differ between the groups with 28-day all-cause mortality significantly lower and intensive care unit-free days significantly shorter in the placebo groups than in the Vit-C groups [5].
T13 1380-1798 Sentence denotes The Vitamin C, hydrocortisone and thiamine in patients with septic shock (VITAMINS) trial also reported that among patients with septic shock, a combination of intravenous Vit-C, hydrocortisone, and thiamine did not significantly improve the primary outcome measure (duration of time alive and free of vasopressor administration over 7 days) compared with that after the intravenous hydrocortisone treatment alone [6].
T14 1799-1968 Sentence denotes Although Vit-C generally exhibits low toxicity, taking >2 g of Vit-C per day may cause adverse gastrointestinal events including abdominal pain, diarrhea, and/or nausea.
T15 1969-2102 Sentence denotes Although Vit-C is a water-soluble vitamin, with excess excreted in the urine, it can contribute to the formation of renal stones [7].
T16 2103-2299 Sentence denotes Additionally, glucose-6-phosphate dehydrogenase (G6PD) deficiency, a genetic condition that results in inadequate G6PD levels, can cause hemolytic anemia following intravenous Vit-C treatment [8].
T17 2300-2406 Sentence denotes Currently, multiple clinical trials investigating the effect of Vit-C on severe COVID-19 are on going [9].
T18 2407-2557 Sentence denotes However, this therapy can only be considered, and therefore incorporated into treatment guidelines, based on sufficient confirmatory research results.
T19 2558-2588 Sentence denotes For now, we will have to wait.